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采用临床和实验室标准协会 M27-A3 肉汤微量稀释参考方法，通过与 48 小时测定比较，验证 24 小时氟胞嘧啶 MIC 测定的有效性。

Validation of 24-hour flucytosine MIC determination by comparison with 48-hour determination by the Clinical and Laboratory Standards Institute M27-A3 broth microdilution reference method.

机构信息

Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop G-11, Atlanta, GA 30333, USA.

出版信息

J Clin Microbiol. 2011 Dec;49(12):4322-5. doi: 10.1128/JCM.05479-11. Epub 2011 Oct 19.

DOI:10.1128/JCM.05479-11
PMID:22012016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3232968/
Abstract

Flucytosine and itraconazole are the only antifungal agents for which the Clinical Laboratory and Standards Institute recommendations include MIC breakpoint readings at 48 h only. Here we show good essential and categorical agreement between the flucytosine MIC readings at 48 and 24 h for Candida species.

摘要

氟胞嘧啶和伊曲康唑是仅有的两种抗真菌药物，临床实验室标准化研究所的建议只包括在 48 小时时的 MIC 折点读数。在这里，我们显示了在 48 小时和 24 小时时氟胞嘧啶 MIC 读数之间对念珠菌属的良好的基本和分类一致性。

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本文引用的文献

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Clinical breakpoints for voriconazole and Candida spp. revisited: review of microbiologic, molecular, pharmacodynamic, and clinical data as they pertain to the development of species-specific interpretive criteria.再次探讨伏立康唑和念珠菌属的临床折点：审查微生物学、分子生物学、药效学和临床数据，以制定与特定种属相关的解释标准。
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Validation of 24-hour posaconazole and voriconazole MIC readings versus the CLSI 48-hour broth microdilution reference method: application of epidemiological cutoff values to results from a global Candida antifungal surveillance program.验证 24 小时泊沙康唑和伏立康唑 MIC 读数与 CLSI 48 小时肉汤微量稀释参考方法的一致性：全球念珠菌抗真菌监测计划中应用流行病学折点值对结果的影响。
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Wild-type MIC distributions, epidemiological cutoff values and species-specific clinical breakpoints for fluconazole and Candida: time for harmonization of CLSI and EUCAST broth microdilution methods.氟康唑和念珠菌的野生型 MIC 分布、流行病学折点值和种特异性临床断点：CLSI 和 EUCAST 肉汤微量稀释方法协调的时机。
Drug Resist Updat. 2010 Dec;13(6):180-95. doi: 10.1016/j.drup.2010.09.002. Epub 2010 Nov 2.
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Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study.ICU 和医院资源利用中不适当的经验性抗真菌治疗与念珠菌血症：一项回顾性队列研究。
BMC Infect Dis. 2010 Jun 3;10:150. doi: 10.1186/1471-2334-10-150.
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Hospital resource utilization and costs of inappropriate treatment of candidemia.不适当治疗念珠菌血症的医院资源利用和成本。
Pharmacotherapy. 2010 Apr;30(4):361-8. doi: 10.1592/phco.30.4.361.
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Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america.《隐球菌病治疗指南：美国传染病学会 2010 年更新版》
Clin Infect Dis. 2010 Feb 1;50(3):291-322. doi: 10.1086/649858.
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Excess mortality, length of stay and cost attributable to candidaemia.念珠菌血症导致的超额死亡率、住院时间及费用
J Infect. 2009 Nov;59(5):360-5. doi: 10.1016/j.jinf.2009.08.020. Epub 2009 Sep 8.
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J Clin Microbiol. 2009 Sep;47(9):2766-71. doi: 10.1128/JCM.00654-09. Epub 2009 Jul 1.
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Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.念珠菌病管理临床实践指南：美国传染病学会2009年更新版
Clin Infect Dis. 2009 Mar 1;48(5):503-35. doi: 10.1086/596757.
10
Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.当按照CLSI M27-A2标准方法检测念珠菌属时，在24小时而非48小时读取氟康唑最低抑菌浓度（MIC）的理论依据。
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