Ostrosky-Zeichner Luis, Rex John H, Pfaller Michael A, Diekema Daniel J, Alexander Barbara D, Andes David, Brown Steven D, Chaturvedi Vishnu, Ghannoum Mahmoud A, Knapp Cindy C, Sheehan Daniel J, Walsh Thomas J
University of Texas Medical School at Houston, Texas 77030, USA.
Antimicrob Agents Chemother. 2008 Nov;52(11):4175-7. doi: 10.1128/AAC.00420-08. Epub 2008 Sep 22.
We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.
我们研究了按照CLSI M27 - A2标准,氟康唑对念珠菌属的最低抑菌浓度(MIC)断点在24小时读取时是否有效。对一组数据集的分析表明,48小时和24小时的MIC之间具有良好的相关性,以及相似的结果和药效学效力参数,但光滑念珠菌等剂量依赖性敏感类别中的分离株除外。