Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
J Mol Histol. 2011 Dec;42(6):567-74. doi: 10.1007/s10735-011-9363-1. Epub 2011 Oct 20.
Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistance (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated. The organ- and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs. The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during IUD in man.
三种 ABC 转运蛋白（MDR1、MRP1、BCRP）属于多药耐药（MDR）蛋白家族，在胚胎发生过程中的保护机制中发挥着关键作用，并介导癌细胞的耐药性。通过间接两步免疫组织化学方法研究了这些转运蛋白在人胚/胎肠、肝和肾系列中不同宫内发育阶段（IUD）的分布。描绘了这些转运蛋白的器官和年龄特异性表达模式，并与成人器官的表达进行了比较。对肠和肝样本的评估表明，在 IUD 期间 ABC 转运蛋白的表达模式存在差异。相反，在肾脏中未观察到年龄特异性定位。然而，从肾脏表面向更深、更分化的部位发现了阳性率的增加。希望我们的研究有助于阐明多药耐药（MDR）途径在人类 IUD 中的作用。
