Division of Rheumatology/Allergy and Clinical Immunology, University of California, Davis, 451 E Health Sciences Drive, Suite 6510 GBSF, Davis, CA 95616, USA.
J Autism Dev Disord. 2012 Jul;42(7):1435-45. doi: 10.1007/s10803-011-1378-7.
Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.
自闭症谱系障碍（ASD）影响美国大约每 110 名儿童中的 1 名。本报告分析了自闭症儿童及其对照儿童的母亲大样本队列中的胎儿脑反应性自身抗体，结果显示 IgG 对 37 和 73 kDa 胎儿脑蛋白的反应性与自闭症的儿童期诊断显著相关（p = 0.0005），这也与表达性语言评分较低相关（p = 0.005）。此外，我们还报告了对 39 和 73 kDa 蛋白的反应性，这与更广泛的 ASD 诊断相关（p = 0.0007），以及在异常行为检查表上的易激惹程度增加（p = 0.05）相关。本研究提供了证据表明，与 ASD 相关的母体抗体对胎儿脑蛋白存在多种反应模式，并且与特定的儿童行为结果相关。
