Department of Biochemistry, Centre for Life Sciences, National University of Singapore, 22 Medical Drive, Singapore, 117456, Singapore.
Genes Nutr. 2012 Apr;7(2):99-109. doi: 10.1007/s12263-011-0255-5. Epub 2011 Oct 20.
Although several epidemiological and intervention studies suggest that polyphenols (PPs) and PP-rich foods may improve memory and cognition in animals and humans, PPs' mode of action is only poorly understood. To help distinguish between the different modes of action that have been proposed for PPs, it is obviously important to know how much PPs can accumulate in the brain, if any at all. However, reliable data on PP uptake into the brain of animals are limited as many studies failed to report important control procedures during data acquisition. In this paper, we summarize published data on the penetration of PPs into animal brain and review some hypotheses to explain the biological basis of potentially health-beneficial effects of PPs to the brain. Finally, we highlight promising new approaches, especially those of a hormetic dose-response and gut microbiota-brain interaction, which may allow a better understanding of PPs' mode of action in animals and humans.
虽然几项流行病学和干预研究表明，多酚（PPs）和富含 PP 的食物可能会改善动物和人类的记忆和认知能力，但 PPs 的作用模式仍知之甚少。为了帮助区分已提出的 PPs 的不同作用模式，显然重要的是要知道 PPs 可以在多大程度上积累在大脑中，如果有的话。然而，由于许多研究在数据采集过程中未能报告重要的控制程序，因此有关动物大脑中 PP 摄取的可靠数据有限。在本文中，我们总结了有关 PPs 穿透动物大脑的已发表数据，并回顾了一些假设，以解释 PPs 对大脑产生潜在健康益处的生物学基础。最后，我们强调了一些有前途的新方法，特别是那些关于有益健康的剂量反应和肠道微生物群-大脑相互作用的方法，这可能有助于更好地了解 PPs 在动物和人类中的作用模式。
