Department of Epidemiology, Brown University, Providence, Rhode Island, USA.
Clin Pharmacol Ther. 2011 Nov;90(5):646-8. doi: 10.1038/clpt.2011.199.
Mandatory registration of observational studies has been proposed to enhance quality of published research and reduce selective publication of positive findings. Enhanced communication of study plans would be welcome, but the alleged benefits to research quality are illusory. In particular, prespecification of hypotheses has no independent effect on data quality or the likelihood that hypotheses are correct. Registration of studies and hypotheses is likely to be misinterpreted as an independent determinant of validity.
已经有人提议对观察性研究进行强制性注册，以提高已发表研究的质量并减少对阳性研究结果的选择性发表。人们欢迎更有效地交流研究计划，但据称对研究质量的好处是虚幻的。特别是，假设的预先指定对数据质量或假设正确的可能性没有独立影响。对研究和假设的注册可能被误解为有效性的独立决定因素。
