Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands.
Appl Microbiol Biotechnol. 2011 Dec;92(5):921-8. doi: 10.1007/s00253-011-3637-0. Epub 2011 Oct 20.
The cell wall, a major barrier protecting cells from their environment, is an essential compartment of both bacteria and archaea. It protects the organism from internal turgor pressure and gives a defined shape to the cell. The cell wall serves also as an anchoring surface for various proteins and acts as an adhesion platform for bacteriophages. The walls of bacteria and archaea are mostly composed of murein and pseudomurein, respectively. Cell wall binding domains play a crucial role in the non-covalent attachment of proteins to cell walls. Here, we give an overview of the similarities and differences in the biochemical and functional properties of the two major murein and pseudomurein cell wall binding domains, i.e., the Lysin Motif (LysM) domain (Pfam PF01476) and the pseudomurein binding (PMB) domain (Pfam PF09373) of bacteria and archaea, respectively.
细胞壁是保护细胞免受其环境影响的主要屏障，是细菌和古菌的重要隔室。它保护生物体免受内部膨压，并赋予细胞特定的形状。细胞壁还作为各种蛋白质的锚定表面，并作为噬菌体的附着平台。细菌和古菌的细胞壁主要由肽聚糖和假肽聚糖组成。细胞壁结合结构域在蛋白质与细胞壁的非共价结合中起着至关重要的作用。在这里，我们概述了两种主要的肽聚糖和假肽聚糖细胞壁结合结构域，即赖氨酰（Lys）基序（LysM）域（Pfam PF01476）和细菌和古菌的假肽聚糖结合（PMB）域（Pfam PF09373）在生化和功能特性上的异同。
