Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom; email:
Annu Rev Cell Dev Biol. 2024 Oct;40(1):1-23. doi: 10.1146/annurev-cellbio-111822-120242. Epub 2024 Sep 21.
Since first identified as a separate domain of life in the 1970s, it has become clear that archaea differ profoundly from both eukaryotes and bacteria. In this review, we look across the archaeal domain and discuss the diverse mechanisms by which archaea control cell cycle progression, DNA replication, and cell division. While the molecular and cellular processes archaea use to govern these critical cell biological processes often differ markedly from those described in bacteria and eukaryotes, there are also striking similarities that highlight both unique and common principles of cell cycle control across the different domains of life. Since much of the eukaryotic cell cycle machinery has its origins in archaea, exploration of the mechanisms of archaeal cell division also promises to illuminate the evolution of the eukaryotic cell cycle.
自 20 世纪 70 年代首次被确定为生命的一个独立领域以来，很明显古菌与真核生物和细菌有很大的不同。在这篇综述中，我们考察了古菌领域，并讨论了古菌控制细胞周期进程、DNA 复制和细胞分裂的多种机制。虽然古菌用来控制这些关键细胞生物学过程的分子和细胞过程通常与细菌和真核生物中描述的过程明显不同，但也有一些惊人的相似之处，突出了不同生命领域中细胞周期控制的独特和共同原则。由于真核细胞周期机制的大部分起源于古菌，因此探索古菌细胞分裂的机制也有望阐明真核细胞周期的进化。
