ROB-1β-内酰胺酶的序列分析与进化观点
Sequence analysis and evolutionary perspectives of ROB-1 beta-lactamase.
作者信息
Juteau J M, Levesque R C
机构信息
Département de Microbiologie, Faculté de Médecine, Université Laval, Quebec, Canada.
出版信息
Antimicrob Agents Chemother. 1990 Jul;34(7):1354-9. doi: 10.1128/AAC.34.7.1354.
Abstract
The nucleotide sequence of the ROB-1 beta-lactamase gene from Haemophilus influenzae plasmid RRob was determined. The structural gene encodes a polypeptide of 305 amino acids, with an estimated molecular mass of 30,424 for the mature form of the protein. The ROB-1 gene showed low homologies with other beta-lactamases at the nucleic acid level. By using two statistical computer methods, assessment of the extent of similarity between ROB-1 and other known beta-lactamase amino acid sequences suggested that ROB-1 is a class A enzyme. Alignment of class A beta-lactamases with ROB-1 identified conserved residues. The use of a mutation matrix for detecting distance relationships indicated that ROB-1 has higher values and homologies with beta-lactamases of gram-positive bacteria, giving insight into its ancestry and divergence.
摘要
测定了来自流感嗜血杆菌质粒RRob的ROB-1β-内酰胺酶基因的核苷酸序列。该结构基因编码一个由305个氨基酸组成的多肽，该蛋白成熟形式的估计分子量为30424。ROB-1基因在核酸水平上与其他β-内酰胺酶的同源性较低。通过使用两种统计计算机方法，评估ROB-1与其他已知β-内酰胺酶氨基酸序列之间的相似程度，结果表明ROB-1是一种A类酶。将A类β-内酰胺酶与ROB-1进行比对，确定了保守残基。使用突变矩阵检测距离关系表明，ROB-1与革兰氏阳性菌的β-内酰胺酶具有更高的值和同源性，这有助于深入了解其起源和分化。
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