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Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.

作者信息

Ahrens-Botzong Annegret, Janthawornpong Karnjapan, Wolny Juliusz A, Tambou Erasmienne Ngouamegne, Rohmer Michel, Krasutsky Sergiy, Poulter C Dale, Schünemann Volker, Seemann Myriam

机构信息

Fachbereich Physik, University of Kaiserslautern, Erwin-Schrödinger-Strasse 46, 67653 Kaiserslautern, Germany.

出版信息

Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11976-9. doi: 10.1002/anie.201104562. Epub 2011 Oct 19.

Abstract
摘要

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本文引用的文献

1
Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation.
J Am Chem Soc. 2011 May 4;133(17):6525-8. doi: 10.1021/ja2008455. Epub 2011 Apr 12.
2
Reductive dehydroxylation of allyl alcohols by IspH protein.
Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8802-9. doi: 10.1002/anie.201000833.
4
Bioorganometallic mechanism of action, and inhibition, of IspH.
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. doi: 10.1073/pnas.0911087107. Epub 2010 Feb 19.
5
Probing the reaction mechanism of IspH protein by x-ray structure analysis.
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1077-81. doi: 10.1073/pnas.0913045107. Epub 2009 Dec 28.
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9
Mechanistic studies of IspH in the deoxyxylulose phosphate pathway: heterolytic C-O bond cleavage at C4 position.
J Am Chem Soc. 2008 Feb 20;130(7):2164-5. doi: 10.1021/ja710245d. Epub 2008 Jan 25.

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