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Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.

作者信息

Ahrens-Botzong Annegret, Janthawornpong Karnjapan, Wolny Juliusz A, Tambou Erasmienne Ngouamegne, Rohmer Michel, Krasutsky Sergiy, Poulter C Dale, Schünemann Volker, Seemann Myriam

机构信息

Fachbereich Physik, University of Kaiserslautern, Erwin-Schrödinger-Strasse 46, 67653 Kaiserslautern, Germany.

出版信息

Angew Chem Int Ed Engl. 2011 Dec 9;50(50):11976-9. doi: 10.1002/anie.201104562. Epub 2011 Oct 19.

DOI:10.1002/anie.201104562
PMID:22012762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3580763/
Abstract
摘要

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本文引用的文献

1
Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation.吡啶抑制剂与 4Fe-4S 蛋白 A. aeolicus IspH(LytB)的结合:HYSCORE 研究。
J Am Chem Soc. 2011 May 4;133(17):6525-8. doi: 10.1021/ja2008455. Epub 2011 Apr 12.
2
Reductive dehydroxylation of allyl alcohols by IspH protein.异戊烯基二磷酸脱水酶蛋白催化烯丙醇的还原脱羟反应。
Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8802-9. doi: 10.1002/anie.201000833.
3
Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms.
微生物()-4-羟基-3-甲基丁-2-烯基焦磷酸还原酶(IspH)及其生物技术潜力:一篇综述。 (注:原文括号处内容缺失,翻译可能会稍显不通顺)
Front Bioeng Biotechnol. 2022 Nov 29;10:1057938. doi: 10.3389/fbioe.2022.1057938. eCollection 2022.
4
The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives.IspH 催化的还原脱羟作用:开发新型抗感染药物的灵感来源
Molecules. 2022 Jan 21;27(3):708. doi: 10.3390/molecules27030708.
5
Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors.配体与IspH结合的光谱学和计算研究:非二磷酸抑制剂的发现
Chembiochem. 2017 May 18;18(10):914-920. doi: 10.1002/cbic.201700052. Epub 2017 Apr 7.
6
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Acta Pharm Sin B. 2015 Nov;5(6):583-9. doi: 10.1016/j.apsb.2015.09.002. Epub 2015 Oct 21.
7
Isoprenoid Biosynthesis in Pathogenic Bacteria: Nuclear Resonance Vibrational Spectroscopy Provides Insight into the Unusual [4Fe-4S] Cluster of the E. coli LytB/IspH Protein.致病细菌中的类异戊二烯生物合成:核磁共振振动光谱揭示大肠杆菌LytB/IspH蛋白中异常的[4Fe-4S]簇
Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12584-7. doi: 10.1002/anie.201502494. Epub 2015 Jun 26.
8
Broken-Symmetry DFT Computations for the Reaction Pathway of IspH, an Iron-Sulfur Enzyme in Pathogenic Bacteria.致病性细菌中一种铁硫酶IspH反应途径的破缺对称密度泛函理论计算
Inorg Chem. 2015 Jul 6;54(13):6439-61. doi: 10.1021/acs.inorgchem.5b00751. Epub 2015 Jun 22.
9
Use of Broken-Symmetry Density Functional Theory To Characterize the IspH Oxidized State: Implications for IspH Mechanism and Inhibition.使用破缺对称性密度泛函理论表征IspH氧化态:对IspH机制及抑制作用的影响
J Chem Theory Comput. 2014 Sep 9;10(9):3871-3884. doi: 10.1021/ct5005214. Epub 2014 Aug 13.
10
Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation.对4Fe-4S蛋白IspG和IspH的抑制作用:一项电子顺磁共振、电子核双共振和高分辨超精细结构谱研究
Chem Sci. 2014 Apr 1;5(4):1642-1649. doi: 10.1039/C3SC53301H.
Fe(4)S(4)- 簇蛋白 IspH(LytB)的抑制作用:电子顺磁共振、金属环和机制。
J Am Chem Soc. 2010 May 19;132(19):6719-27. doi: 10.1021/ja909664j.
4
Bioorganometallic mechanism of action, and inhibition, of IspH.IspH 的生物有机金属作用机制及抑制作用。
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4522-7. doi: 10.1073/pnas.0911087107. Epub 2010 Feb 19.
5
Probing the reaction mechanism of IspH protein by x-ray structure analysis.通过 X 射线结构分析探究 IspH 蛋白的反应机制。
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1077-81. doi: 10.1073/pnas.0913045107. Epub 2009 Dec 28.
6
Isoprenoid biosynthesis via the MEP pathway: in vivo Mössbauer spectroscopy identifies a [4Fe-4S]2+ center with unusual coordination sphere in the LytB protein.异戊烯基生物合成途径:体内穆斯堡尔谱学鉴定 LytB 蛋白中具有异常配位环境的 [4Fe-4S]2+中心。
J Am Chem Soc. 2009 Sep 23;131(37):13184-5. doi: 10.1021/ja9012408.
7
Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction.来自大肠杆菌的活性IspH酶的结构为底物还原提供了机制上的见解。
Angew Chem Int Ed Engl. 2009;48(31):5756-9. doi: 10.1002/anie.200900548.
8
Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway.(E)-4-羟基-3-甲基-丁-2-烯基二磷酸还原酶的结构,非甲羟戊酸途径的末端酶。
J Am Chem Soc. 2008 Dec 24;130(51):17206-7. doi: 10.1021/ja806668q.
9
Mechanistic studies of IspH in the deoxyxylulose phosphate pathway: heterolytic C-O bond cleavage at C4 position.脱氧木酮糖磷酸途径中IspH的机制研究:C4位的异裂碳-氧键断裂
J Am Chem Soc. 2008 Feb 20;130(7):2164-5. doi: 10.1021/ja710245d. Epub 2008 Jan 25.
10
Isoprenoid biosynthesis as a novel target for antibacterial and antiparasitic drugs.类异戊二烯生物合成作为抗菌和抗寄生虫药物的新靶点。
Curr Opin Investig Drugs. 2004 Feb;5(2):154-62.