Department of Gene Expression, Faculty of Biology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Umultowska 89, 61-614 Poznan, Poland.
Nucleic Acids Res. 2012 Jan;40(Database issue):D191-7. doi: 10.1093/nar/gkr878. Epub 2011 Oct 19.
mirEX is a comprehensive platform for comparative analysis of primary microRNA expression data. RT-qPCR-based gene expression profiles are stored in a universal and expandable database scheme and wrapped by an intuitive user-friendly interface. A new way of accessing gene expression data in mirEX includes a simple mouse operated querying system and dynamic graphs for data mining analyses. In contrast to other publicly available databases, the mirEX interface allows a simultaneous comparison of expression levels between various microRNA genes in diverse organs and developmental stages. Currently, mirEX integrates information about the expression profile of 190 Arabidopsis thaliana pri-miRNAs in seven different developmental stages: seeds, seedlings and various organs of mature plants. Additionally, by providing RNA structural models, publicly available deep sequencing results, experimental procedure details and careful selection of auxiliary data in the form of web links, mirEX can function as a one-stop solution for Arabidopsis microRNA information. A web-based mirEX interface can be accessed at http://bioinfo.amu.edu.pl/mirex.
mirEX 是一个用于初级 microRNA 表达数据比较分析的综合平台。基于 RT-qPCR 的基因表达谱存储在一个通用且可扩展的数据库方案中，并由直观的用户友好界面包装。访问 mirEX 中基因表达数据的一种新方法包括一个简单的鼠标操作查询系统和用于数据挖掘分析的动态图。与其他可用的公共数据库不同，mirEX 界面允许在不同的器官和发育阶段同时比较各种 microRNA 基因的表达水平。目前，mirEX 整合了 190 个拟南芥 pri-miRNA 在七个不同发育阶段的表达谱信息：种子、幼苗和成熟植物的各种器官。此外，通过提供 RNA 结构模型、公开的深度测序结果、实验程序细节以及以网络链接形式精心选择的辅助数据，mirEX 可以作为拟南芥 microRNA 信息的一站式解决方案。可以在 http://bioinfo.amu.edu.pl/mirex 访问基于网络的 mirEX 界面。
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