Michigan State University-DOE Plant Research Laboratory, Michigan State University, East Lansing, MI 48824, USA.
Trends Plant Sci. 2010 Sep;15(9):522-8. doi: 10.1016/j.tplants.2010.05.010. Epub 2010 Jun 16.
The secretory pathway encloses functionally interlinked organelles for the synthesis and deposition of most of the building blocks of eukaryotic cells, such as lipids, proteins and sugars. The coat protein complex II (COPII) is a specialized protein complex for the transport between secretory organelles, specifically from the endoplasmic reticulum (ER) to the Golgi apparatus. This review focuses on the developments on COPII research in the plant system. Here, we address the most recent advances in the distribution and regulation of ER-to-Golgi protein transport intermediates and functional analyses of COPII isoforms. New studies support that such isoforms might not be functionally redundant and that they might have unanticipated roles in maintaining the integrity of the ER.
分泌途径将功能上相互关联的细胞器包裹起来，用于合成和沉积真核细胞的大多数构建块，如脂质、蛋白质和糖。囊泡蛋白复合物 II（COPII）是一种用于在分泌细胞器之间进行运输的特殊蛋白复合物，特别是从内质网（ER）到高尔基体。本综述重点介绍了植物系统中 COPII 研究的最新进展。在这里，我们讨论了 ER 到高尔基体蛋白运输中间产物的分布和调节以及 COPII 同工型的功能分析的最新进展。新的研究支持这样的同工型可能在功能上不是冗余的，并且它们可能在维持 ER 的完整性方面具有意想不到的作用。
