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[卡托普利试验在原发性醛固酮增多症诊断中的意义——附4例临床病例]

[Significance of the captopril test in the diagnosis of primary hyperaldosteronism --apropos of 4 clinical cases].

作者信息

Proença R, Machado J, Maltez F, Alberto M J, Martins G, Gonçalves P

机构信息

Hospital de Curry Cabral, Serviço 1.

出版信息

Rev Port Cardiol. 1990 Apr;9(4):333-7.

PMID:2201322
Abstract

We describe four cases of primary hyperaldosteronism whose initial presentation was a moderate to severe hypertension. In three patients an adrenal adenoma was found; in another patient was due to unilateral adrenal hyperplasia. A good therapeutic response was achieved in all cases by unilateral adrenalectomy. The captopril test (Lyons version) proved useful to exclude essential hypertension and, may be, in distinguishing the new sub-types of primary hyperaldosteronism recently described. Indeed, only in the case of unilateral adrenal hyperplasia a fall in plasma aldosterone levels was observed. However, we feel that further investigation is needed to clarify this point.

摘要

我们描述了4例原发性醛固酮增多症患者,其最初表现为中度至重度高血压。3例患者发现肾上腺腺瘤;另1例患者病因是单侧肾上腺增生。所有病例通过单侧肾上腺切除术均取得了良好的治疗效果。卡托普利试验(莱昂斯版本)被证明有助于排除原发性高血压,或许还有助于区分最近描述的原发性醛固酮增多症新亚型。事实上,仅在单侧肾上腺增生的病例中观察到血浆醛固酮水平下降。然而,我们认为需要进一步研究以阐明这一点。

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