Nilsson S, Erikson U
Department of Diagnostic Radiology, Akademiska Sjukhuset, University of Uppsala, Sweden.
Acta Radiol. 1990 May;31(3):249-57.
To evaluate the effects of treatment in patients with cardiovascular risk factors, valid and reproducible methods for assessing changes in atheroma volume are required. We postulated that these changes could be accurately estimated by repeat measurement of the lumen volume of the artery to be studied. With a computer-based technique, the lumen volume of a 20 cm segment of the femoral artery was measured in arteriograms from 107 patients with hypercholesterolemia. Films were digitized with use of a high-resolution scanner, cross-sectional areas were calculated with a slice thickness of 150 microns and the lumen volume was obtained by their integration. The validity of the method was demonstrated in model experiments. An automatic algorithm to correct for changes due to patient positioning was developed and validated in a model experiment. With repeat measurement 10 min and 11 to 13 months apart the coefficients of variation were 2.9 per cent (N = 107) and 6.1 per cent (N = 29), respectively.
为评估心血管危险因素患者的治疗效果，需要有效且可重复的方法来评估动脉粥样硬化体积的变化。我们推测，通过重复测量待研究动脉的管腔体积可准确估计这些变化。利用基于计算机的技术，在107例高胆固醇血症患者的动脉造影片中测量了股动脉20厘米节段的管腔体积。使用高分辨率扫描仪将影片数字化，以150微米的切片厚度计算横截面面积，并通过积分获得管腔体积。该方法的有效性在模型实验中得到了证实。开发了一种自动算法来校正因患者体位改变而引起的变化，并在模型实验中进行了验证。间隔10分钟和11至13个月重复测量时，变异系数分别为2.9%（N = 107）和6.1%（N = 29）。
