Nilsson S, Kaijser L, Erikson U, Johansson J, Walldius G
Department of Diagnostic Radiology, Akademiska Sjukhuset, Uppsala, Sweden.
Clin Physiol. 1992 Jan;12(1):53-68. doi: 10.1111/j.1475-097x.1992.tb00293.x.
The validity of computer-assisted femoral arteriography, for the study of regression/progression of atherosclerosis in follow-up clinical trials, was investigated by comparison with routine physiological estimates of peripheral circulatory function. Thus, in 114 hypercholesterolaemic patients, the results of aorto-femoral arteriography were compared with those of leg segmental blood pressure measurement, oscillometry, digital pulse plethysmography, and bicycle and treadmill exercise tests. In 107 patients, 18 with symptoms of peripheral vascular disease (PVD) and 89 asymptomatic, magnification arteriograms of a 20 cm segment of the right or left superficial femoral artery were obtained. These arteriograms were digitized and the following variables were calculated: arterial lumen volume (corrected for body size), per cent stenosis, and edge roughness. The correlation between arteriographic and physiological variables was investigated with a linear regression model, taking into account the possible interaction with sex, and presence or absence of symptoms of PVD. Lumen volume correlated significantly with all five physiological variables, and per cent stenosis correlated significantly with four of the physiological variables. For the roughness measure, however a significant correlation was found only with plethysmography. By using logistic multiple regression analysis linear functions of physiological variables were constructed to detect ilio-femoral arterial occlusion. The sensitivity/specificity for detection of right-sided, left-sided, and bilateral occlusion was 0.83/0.98, 0.78/0.98, and 0.60/1.00 respectively (N = 108-111). Systolic blood pressure (ankle-arm ratio) was the single variable most closely correlated to the likelihood of arterial occlusions. It is concluded that arterial lumen volume and per cent stenosis, measured for the digitized femoral arteriogram, correlate well with physiological variables, which reflect the state of atherosclerosis both in the femoral arteries and in other arterial beds including the heart, and that routine physiological tests can be used to identify patients with arterial occlusions in the iliac and femoral arteries.
通过与外周循环功能的常规生理学评估进行比较，研究了计算机辅助股动脉造影在后续临床试验中用于动脉粥样硬化消退/进展研究的有效性。因此，在114例高胆固醇血症患者中，将腹主动脉-股动脉造影的结果与腿部节段性血压测量、示波法、数字脉搏容积描记法以及自行车和跑步机运动试验的结果进行了比较。在107例患者中，18例有外周血管疾病（PVD）症状，89例无症状，获取了右侧或左侧股浅动脉20 cm节段的放大动脉造影图像。这些动脉造影图像被数字化，并计算了以下变量：动脉管腔容积（根据身体大小校正）、狭窄百分比和边缘粗糙度。采用线性回归模型研究动脉造影变量与生理变量之间的相关性，同时考虑到与性别以及PVD症状的有无之间可能存在的相互作用。管腔容积与所有五个生理变量均显著相关，狭窄百分比与四个生理变量显著相关。然而，对于粗糙度测量，仅与容积描记法发现有显著相关性。通过使用逻辑多元回归分析，构建了生理变量的线性函数以检测髂股动脉闭塞。检测右侧、左侧和双侧闭塞的敏感性/特异性分别为0.83/0.98、0.78/0.98和0.60/1.00（N = 108 - 111）。收缩压（踝臂指数）是与动脉闭塞可能性最密切相关的单一变量。结论是，数字化股动脉造影测量的动脉管腔容积和狭窄百分比与生理变量密切相关，这些生理变量反映了股动脉以及包括心脏在内的其他动脉床的动脉粥样硬化状态，并且常规生理测试可用于识别髂动脉和股动脉有闭塞的患者。
