Sobrino-Vegas Paz, Pérez-Hoyos Santiago, Geskus Ronald, Padilla Belén, Segura Ferrán, Rubio Rafael, Del Romero Jorge, Santos Jesus, Moreno Santiago, Del Amo Julia
Red de Investigación en Sida, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, 28029 Madrid, Spain.
AIDS Res Treat. 2012;2012:725412. doi: 10.1155/2012/725412. Epub 2011 Oct 15.
Objectives. Since subjects may have been diagnosed before cohort entry, analysis of late HIV diagnosis (LD) is usually restricted to the newly diagnosed. We estimate the magnitude and risk factors of LD in a cohort of seroprevalent individuals by imputing seroconversion dates. Methods. Multicenter cohort of HIV-positive subjects who were treatment naive at entry, in Spain, 2004-2008. Multiple-imputation techniques were used. Subjects with times to HIV diagnosis longer than 4.19 years were considered LD. Results. Median time to HIV diagnosis was 2.8 years in the whole cohort of 3,667 subjects. Factors significantly associated with LD were: male sex; Sub-Saharan African, Latin-American origin compared to Spaniards; and older age. In 2,928 newly diagnosed subjects, median time to diagnosis was 3.3 years, and LD was more common in injecting drug users. Conclusions. Estimates of the magnitude and risk factors of LD for the whole cohort differ from those obtained for new HIV diagnoses.
目的。由于受试者可能在队列入组前已被诊断，晚期HIV诊断（LD）的分析通常仅限于新诊断的患者。我们通过推算血清转换日期来估计一组血清阳性个体中LD的程度和危险因素。方法。2004 - 2008年在西班牙进行的多中心队列研究，入组时未接受过治疗的HIV阳性受试者。采用多重填补技术。HIV诊断时间超过4.19年的受试者被视为LD。结果。在3667名受试者的整个队列中，HIV诊断的中位时间为2.8年。与LD显著相关的因素有：男性；与西班牙人相比，撒哈拉以南非洲、拉丁美洲血统；以及年龄较大。在2928名新诊断的受试者中，诊断的中位时间为3.3年，LD在注射吸毒者中更常见。结论。整个队列中LD的程度和危险因素的估计与新HIV诊断的估计不同。
