Andrology Department, Cairo University, Cairo, Egypt.
Andrologia. 2012 May;44 Suppl 1:650-3. doi: 10.1111/j.1439-0272.2011.01244.x. Epub 2011 Oct 20.
Premature ejaculation (PE) is by far the most common male sexual complaint, with millions of men affected all over the world. It is estimated that up to 20-30% of all men may be suffering from various forms of PE. A variety of filler materials are widely used nowadays for soft tissue augmentation. The appropriate filler can restore symmetry, volume and create a smooth skin surface The aim of this pilot study was to evaluate the therapeutic effect of hyaluronic acid gel injection in patients with PE. Sixty men with self-reported PE who were referred to our outpatient andrology clinic (between January 2007 and January 2008) were included in this study. Participants were randomly assigned using random sampling numbers into two distinct groups. Group A (n = 30) received a single injection of 2 ml of hyaluronic acid gel (Hyalift 3.5% micronised hyaluronic acid) using the previously described fan technique. Group B (n = 30) received a single injection of 2 ml of hyaluronic acid gel using the multiple puncture technique. Twenty-three patients (46.9%) received injection by the fan technique, while 26 patients (53.1%) received it through the multiple-point technique. The mean intravaginal ejaculation latency time (IELT) increased significantly from 2.12 ± 1.16 to 7.71 ± 7.86 min, after 1 month of injection and then dropped to 5.32 ± 3.52 min, but still remaining significantly higher than the baseline values. Results from our present pilot study demonstrated the usefulness of the application of hyaluronic acid dermal fillers in the treatment of PE; however, further investigations in large cohorts with longer follow-up are definitely needed to obtain more consistent results.
早泄（PE）是迄今为止最常见的男性性功能障碍，全世界有数百万男性受到影响。据估计，多达 20-30%的男性可能患有各种形式的 PE。目前广泛使用各种填充物材料进行软组织填充。适当的填充物可以恢复对称性、体积并使皮肤表面光滑。本研究旨在评估透明质酸凝胶注射治疗 PE 的疗效。本研究纳入了 2007 年 1 月至 2008 年 1 月期间因早泄而到我们的男科门诊就诊的 60 名男性。参与者采用随机数字表法随机分为两组。A 组（n=30）采用扇形注射技术，每侧阴茎海绵体注射 2ml 3.5%微交联透明质酸凝胶（Hyalift）。B 组（n=30）采用多点注射技术，每侧阴茎海绵体注射 2ml 透明质酸凝胶。23 名患者（46.9%）采用扇形注射技术，26 名患者（53.1%）采用多点注射技术。注射后 1 个月，患者的阴道内射精潜伏期（IELT）从 2.12±1.16 分钟显著增加到 7.71±7.86 分钟，然后下降到 5.32±3.52 分钟，但仍明显高于基线水平。本研究结果表明，应用透明质酸真皮填充剂治疗 PE 是有效的；然而，需要进一步在更大队列中进行更长时间的随访，以获得更一致的结果。
