Sakr Ahmed, Elgalaly Hazem, Seleem Mohamed M, Kamel Mostafa, El-Sakka Ahmed I, Ibrahim Ibrahim M
Faculty of Medicine, Urology Department, Zagazig University, Zagazig, Egypt.
Faculty of Medicine, Urology Department, Suez Canal University, Ismailia, Egypt.
Arab J Urol. 2022 Jul 19;21(1):31-35. doi: 10.1080/2090598X.2022.2100580. eCollection 2023.
To assess safety and efficacy of hyaluronic acid (HA) gel injection in glans penis for treatment of premature ejaculation (PE) using our new five puncture technique.
This is a prospective, non-randomized clinical trial on HA gel injection in glans penis for all patients with lifelong PE; all patients were circumcised having heterosexual normal marital life and sexually active. Patients with history of ejaculatory medication use within the previous 3 months, psychiatric disorders, erectile dysfunction, lower urinary tract symptoms (LUTS) due to prostatitis and acquired PE were excluded from the study. A local anesthetic was applied to the skin of glans penis for 30 minutes before the injection of 2 ml HA in glans penis via 30-gauge needle using our new Five-puncture technique. Intra-vaginal ejaculatory latency time (IELT) was measured at 1, 3, 6 and 12 months after injection.
Thirty patients completed our study follow up schedule. Mean age of the patients was 41.72 ± 8.50, while mean age of female partner was 37.23 ± 8.54 years. IELT was highly significantly increased (-value < 0.001) after HA gel injection from baseline, which was in maximum 37.83 ± 11.01 sec at baseline to 323.03 ± 42.06, 281.07 ± 41.05, 241.03 ± 43.09 and 235.6 ± 41.87 sec after 1, 3, 6 and 12 months, respectively, after injection. Three patients complained from discomfort at the site of injection, two from bullae formation at the site of injection and one from ecchymosis, and all resolved spontaneously after 1 week to 10 days after injection.
HA gel injection in glans penis using our new five-puncture technique is a safe and effective method that ensures a modest long-term significant increase in IELT and improves ejaculatory control.
采用我们新的五点穿刺技术，评估阴茎头注射透明质酸（HA）凝胶治疗早泄（PE）的安全性和有效性。
这是一项针对所有终生性早泄患者进行阴茎头HA凝胶注射的前瞻性、非随机临床试验；所有患者均行包皮环切术，有异性正常婚姻生活且性活跃。排除在过去3个月内有射精药物使用史、精神疾病、勃起功能障碍、因前列腺炎导致的下尿路症状（LUTS）以及获得性早泄的患者。在通过30号针头使用我们新的五点穿刺技术向阴茎头注射2ml HA之前，将局部麻醉剂涂抹在阴茎头皮肤上30分钟。在注射后1、3、6和12个月测量阴道内射精潜伏期（IELT）。
30例患者完成了我们的研究随访计划。患者的平均年龄为41.72±8.50岁，而女性伴侣的平均年龄为37.23±8.54岁。注射HA凝胶后，IELT较基线有极显著增加（P值<0.001），基线时最长为37.83±11.01秒，注射后1、3、6和12个月分别为323.03±42.06、281.07±41.05、241.03±43.09和235.6±41.87秒。3例患者抱怨注射部位不适，2例抱怨注射部位形成水疱，1例抱怨出现瘀斑，所有这些在注射后1周内至10天均自行缓解。
采用我们新的五点穿刺技术在阴茎头注射HA凝胶是一种安全有效的方法，可确保IELT适度长期显著增加，并改善射精控制。
