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晚期前列腺癌中的芳香化酶抑制：初步交流。

Aromatase inhibition in advanced prostatic cancer: preliminary communication.

作者信息

Shearer R J, Davies J H, Dowsett M, Malone P R, Hedley A, Cunningham D, Coombes R C

机构信息

Department of Urology, St Georges Hospital, Tooting, London, UK.

出版信息

Br J Cancer. 1990 Aug;62(2):275-6. doi: 10.1038/bjc.1990.276.

DOI:10.1038/bjc.1990.276
PMID:2201397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1971817/
Abstract

We report the results of the first use of a steroidal aromatase inhibitor, 4-hydroxyandrostenedione (4-OHA, CGP 32349), in the palliation of patients with advanced, hormone resistant, prostatic cancer. Twelve of 19 patients (63%), who had relapsed following castration and other therapies, gained significant pain relief following weekly intramuscular injections of 4-OHA. Five patients (31%) experienced a transient 'tumour flare', represented by an increase in bone pain soon after commencing treatment. The mechanism of action of 4-OHA in palliating patients with advanced prostatic cancer is obscure at present, but may represent an important new treatment modality which may lead to greater insight into prostatic biology.

摘要

我们报告了首次使用甾体类芳香化酶抑制剂4-羟基雄烯二酮（4-OHA，CGP 32349）缓解晚期激素抵抗性前列腺癌患者症状的结果。19例在去势及其他治疗后复发的患者中，12例（63%）在每周肌肉注射4-OHA后疼痛得到显著缓解。5例患者（31%）经历了短暂的“肿瘤flare”，表现为开始治疗后不久骨痛加剧。目前，4-OHA缓解晚期前列腺癌患者症状的作用机制尚不清楚，但可能代表一种重要的新治疗方式，这可能会使我们对前列腺生物学有更深入的了解。

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本文引用的文献

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Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo.4-羟基-4-雄烯-3,17-二酮和4-乙酰氧基-4-雄烯-3,17-二酮在体外对芳香化酶的失活作用及其在体内的持续效应
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Androgen suppression by hydrocortisone without aminoglutethimide in orchiectomised men with prostatic cancer.
Br J Urol. 1987 Mar;59(3):255-7. doi: 10.1111/j.1464-410x.1987.tb04617.x.
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The effects of aminoglutethimide and hydrocortisone, alone and combined, on androgen levels in post-orchiectomy prostatic cancer patients.氨鲁米特和氢化可的松单独及联合使用对睾丸切除术后前列腺癌患者雄激素水平的影响。
Br J Cancer. 1988 Feb;57(2):190-2. doi: 10.1038/bjc.1988.40.

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