晚期前列腺癌对氨鲁米特和醋酸可的松的反应
Response to aminoglutethimide and cortisone acetate in advanced prostatic cancer.
作者信息
Ponder B A, Shearer R J, Pocock R D, Miller J, Easton D, Chilvers C E, Dowsett M, Jeffcoate S L
出版信息
Br J Cancer. 1984 Dec;50(6):757-63. doi: 10.1038/bjc.1984.253.
Abstract
Forty patients with metastatic adenocarcinoma of the prostate were evaluated for response to treatment with aminoglutethimide plus cortisone acetate. All had relapsed from or failed to respond to primary endocrine treatment with orchidectomy or stilboestrol. Nineteen patients (48%) showed subjective response, in most cases relief of bone pain. Side effects limited treatment in only 3 patients. We conclude that aminoglutethimide plus cortisone acetate is a useful addition to the treatment available for this difficult group of patients. The mechanism by which this treatment has a beneficial effect remains unclear.
摘要
对40例前列腺转移性腺癌患者进行了评估，以确定其对氨鲁米特加醋酸可的松治疗的反应。所有患者均已从睾丸切除术或己烯雌酚的初始内分泌治疗中复发或治疗无效。19例患者（48%）出现主观反应，多数情况下骨痛缓解。仅3例患者因副作用限制了治疗。我们得出结论，氨鲁米特加醋酸可的松是治疗这类难治性患者现有方法的有益补充。这种治疗产生有益效果的机制尚不清楚。
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