Neuroscience Department, University of Pisa, Pisa, Italy.
J Int Neuropsychol Soc. 2011 Nov;17(6):1158-62. doi: 10.1017/S1355617711001214. Epub 2011 Oct 12.
The present study investigated memory for intention in individuals with Parkinson's disease (PD) who were newly diagnosed and not yet treated to avoid the effect of therapy as a potential confounding variable. A comprehensive neuropsychological battery and an event-based prospective memory task were administered to 41 subjects with de novo PD and 40 control subjects. Separate scores were computed for correct execution of intended action (prospective component) and recall of intention (retrospective component). PD patients performed marginally worse (p = .053) than controls on the prospective component of the task. On the other hand, the performance of the two groups was comparable for the retrospective component. Neuropsychological findings revealed lower performance of the PD group in episodic memory and in some measures of executive functions. These results suggested a subtle prospective memory dysfunction present at the initial stage of PD, which may be related to disruption of fronto-striatal circuitry.
本研究旨在调查新诊断且尚未接受治疗以避免治疗效果成为潜在混杂变量的帕金森病（PD）患者的意图记忆。对 41 名初诊 PD 患者和 40 名对照组受试者进行了全面的神经心理学测试和基于事件的前瞻性记忆任务。分别计算了正确执行预期动作（前瞻性成分）和回忆意图（回溯性成分）的分数。PD 患者在任务的前瞻性成分上的表现略差（p=0.053）于对照组。另一方面，两组在回溯性成分上的表现相当。神经心理学结果显示，PD 组在情景记忆和一些执行功能测试中表现较差。这些结果表明，PD 初始阶段存在微妙的前瞻性记忆障碍，可能与额纹状体回路的破坏有关。
