Department of Psychology, National Taiwan University, Taipei, Taiwan.
Mov Disord. 2010 Jun 15;25(8):1034-9. doi: 10.1002/mds.23017.
The aim of this study was to examine metamemory in patients with Parkinson's disease (PD) with different dominant motor symptoms. This is a prospective case-control study. Fifty-five PD patients [25 patients with tremor-dominant (TD) motor symptoms and 30 patients with akinetic and rigidity-dominant (ARD) motor symptoms] and 30 normal controls were studied. The two patient groups were similar in terms of age, level of education, disease duration, and disease severity. Metamemory was measured using the experimental metamemory task [feeling-of-knowing (FOK) paradigm]. In addition, memory and executive functions were determined using detailed cognitive tests. In comparison with normal subjects and TD patients, ARD patients exhibited impaired FOK accuracy (P = 0.007). Furthermore, correlation analysis revealed an intergroup differential pattern, which indicated that FOK accuracy was primarily related to memory ability in ARD patients and executive function in TD patients. Our results provide evidence of impaired metamemory in the early stages of PD with ARD rather than TD motor symptoms. These findings might be useful for designing specific medical care strategies for ARD patients. Further studies are needed to determine whether impaired metamemory is an early predictor for brain alteration in PD patients.
本研究旨在探讨不同主导运动症状的帕金森病（PD）患者的元记忆。这是一项前瞻性病例对照研究。研究纳入 55 例 PD 患者[25 例震颤为主（TD）运动症状和 30 例无动性和僵硬为主（ARD）运动症状]和 30 名正常对照。两组患者在年龄、教育程度、病程和疾病严重程度方面相似。使用实验性元记忆任务（感觉知道（FOK）范式）测量元记忆。此外，使用详细的认知测试来确定记忆和执行功能。与正常受试者和 TD 患者相比，ARD 患者的 FOK 准确性受损（P = 0.007）。此外，相关性分析显示出组间差异模式，表明 FOK 准确性主要与 ARD 患者的记忆能力和 TD 患者的执行功能相关。我们的结果提供了 ARD 而不是 TD 运动症状的 PD 早期阶段元记忆受损的证据。这些发现可能有助于为 ARD 患者设计特定的医疗保健策略。需要进一步研究以确定元记忆受损是否是 PD 患者脑改变的早期预测指标。
