• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

那么，我们现在应该如何称呼 GPR18 呢？

So what do we call GPR18 now?

机构信息

School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, UK.

出版信息

Br J Pharmacol. 2012 Apr;165(8):2411-3. doi: 10.1111/j.1476-5381.2011.01731.x.

DOI:10.1111/j.1476-5381.2011.01731.x
PMID:22014123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3423231/
Abstract

The further characterization of the orphan GPCR GPR18 conducted by McHugh et al. in this issue of the British Journal of Pharmacology has generated a pharmacological profile that raises some interesting questions about the nomenclature of this receptor and may also prompt some questions about the pharmacological definition of the classical cannabinoid receptors, CB(1) and CB(2) . LINKED ARTICLES This article is a commentary on McHugh et al., pp. 2414-2424 of this issue and is part of a themed section on Cannabinoids in Biology and Medicine. To view McHugh et al. visit http://dx.doi.org/10.1111/j.1476-5381.2011.01497.x. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-8. To view Part I of Cannabinoids in Biology and Medicine visit http://dx.doi.org/10.1111/bph.2011.163.issue-7.

摘要

麦克休等人在本期《英国药理学杂志》上对孤儿 G 蛋白偶联受体 GPR18 的进一步研究，提供了一个药理学特征，这引发了一些关于该受体命名的有趣问题，也可能对经典大麻素受体 CB(1) 和 CB(2) 的药理学定义提出一些质疑。

相关文章 本文是对麦克休等人在本期杂志上发表的关于 GPR18 的研究的评论，也是生物与医学中的大麻素这一专题的一部分。要查看麦克休等人的文章，请访问 http://dx.doi.org/10.1111/j.1476-5381.2011.01497.x。要查看该专题中的其他文章，请访问 http://dx.doi.org/10.1111/bph.2012.165.issue-8。要查看生物与医学中的大麻素的第一部分，请访问 http://dx.doi.org/10.1111/bph.2011.163.issue-7。

相似文献

1
So what do we call GPR18 now?那么，我们现在应该如何称呼 GPR18 呢？
Br J Pharmacol. 2012 Apr;165(8):2411-3. doi: 10.1111/j.1476-5381.2011.01731.x.
2
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.Δ(9)-四氢大麻酚和 N-花生四烯酰甘氨酸是 GPR18 受体的完全激动剂，可诱导人子宫内膜 HEC-1B 细胞迁移。
Br J Pharmacol. 2012 Apr;165(8):2414-24. doi: 10.1111/j.1476-5381.2011.01497.x.
3
GPR18 in microglia: implications for the CNS and endocannabinoid system signalling.小胶质细胞中的 GPR18：对中枢神经系统和内源性大麻素系统信号转导的影响。
Br J Pharmacol. 2012 Dec;167(8):1575-82. doi: 10.1111/j.1476-5381.2012.02019.x.
4
Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones.人源大麻素 CB1 受体及其剪接变异体在自突触海马神经元中的差异信号转导。
Br J Pharmacol. 2012 Apr;165(8):2660-71. doi: 10.1111/j.1476-5381.2011.01744.x.
5
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.N-花生四烯酰甘氨酸是一种丰富的内源性脂质，通过假定的异常大麻素受体 GPR18 强烈驱动定向细胞迁移。
BMC Neurosci. 2010 Mar 26;11:44. doi: 10.1186/1471-2202-11-44.
6
Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.大麻素化合物对GPR18的激活：偏向性激动作用的故事。
Br J Pharmacol. 2014 Aug;171(16):3908-17. doi: 10.1111/bph.12746.
7
Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro.大麻素与骨骼：内源性大麻素调节人破骨细胞体外功能。
Br J Pharmacol. 2012 Apr;165(8):2584-97. doi: 10.1111/j.1476-5381.2011.01519.x.
8
The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.G 蛋白偶联受体相关分拣蛋白 1 调节 GPR55 配体诱导的下调。
Br J Pharmacol. 2012 Apr;165(8):2611-9. doi: 10.1111/j.1476-5381.2011.01562.x.
9
Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors.Δ8-四氢大麻素通过大麻素 CB2 受体减少氧化应激和炎症反应来预防肝缺血/再灌注损伤。
Br J Pharmacol. 2012 Apr;165(8):2450-61. doi: 10.1111/j.1476-5381.2011.01410.x.
10
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.大麻素 CB1 受体拮抗剂利莫那班（SR141716）和 AM251 直接增强 GABA(A) 受体。
Br J Pharmacol. 2012 Apr;165(8):2479-84. doi: 10.1111/j.1476-5381.2011.01405.x.

引用本文的文献

1
Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders.新型 GPR18 配体在啮齿动物药理学试验中的作用：对情绪、疼痛和饮食失调的影响。
Int J Mol Sci. 2023 May 20;24(10):9046. doi: 10.3390/ijms24109046.
2
Cannabinoids, their cellular receptors, and effects on the invasive phenotype of carcinoma and metastasis.大麻素、其细胞受体以及对癌和转移侵袭表型的影响。
Cancer Rep (Hoboken). 2022 Feb;5(2):e1475. doi: 10.1002/cnr2.1475. Epub 2021 Jul 26.
3
Phytocannabinoids Biosynthesis in Angiosperms, Fungi, and Liverworts and Their Versatile Role.被子植物、真菌和地钱中的植物大麻素生物合成及其多功能作用。
Plants (Basel). 2021 Jun 28;10(7):1307. doi: 10.3390/plants10071307.
4
Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18.三环黄嘌呤作为大麻素激活的孤儿G蛋白偶联受体GPR18激动剂的发现。
ACS Med Chem Lett. 2020 Jun 17;11(10):2024-2031. doi: 10.1021/acsmedchemlett.0c00208. eCollection 2020 Oct 8.
5
ETS2 and microRNA-155 regulate the pathogenesis of heart failure through targeting and regulating GPR18 expression.ETS2和微小RNA-155通过靶向和调节GPR18表达来调控心力衰竭的发病机制。
Exp Ther Med. 2020 Jun;19(6):3469-3478. doi: 10.3892/etm.2020.8642. Epub 2020 Apr 3.
6
Potential metabolic and behavioural roles of the putative endocannabinoid receptors GPR18, GPR55 and GPR119 in feeding.潜在代谢和行为的作用的假定内源性大麻素受体 GPR18、 GPR55 和 GPR119 在摄食。
Curr Neuropharmacol. 2019;17(10):947-960. doi: 10.2174/1570159X17666190118143014.
7
Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.促炎消退介质促进人类皮肤模型中 UV 杀死的大肠杆菌驱动的急性炎症消退。
JCI Insight. 2018 Mar 22;3(6):94463. doi: 10.1172/jci.insight.94463.
8
Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats.解析 D2 型 resolvin 可保护大鼠免受脑缺血/再灌注损伤。
Mol Brain. 2018 Feb 13;11(1):9. doi: 10.1186/s13041-018-0351-1.
9
Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.延髓头端腹外侧区中神经元型一氧化氮合酶依赖性脂联素升高是G蛋白偶联受体18介导的清醒大鼠低血压的基础。
J Pharmacol Exp Ther. 2014 Oct;351(1):44-53. doi: 10.1124/jpet.114.216036. Epub 2014 Aug 6.
10
Endothelial atypical cannabinoid receptor: do we have enough evidence?内皮非典型大麻素受体：我们有足够的证据吗？
Br J Pharmacol. 2014 Dec;171(24):5573-88. doi: 10.1111/bph.12866.

本文引用的文献

1
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.Δ(9)-四氢大麻酚和 N-花生四烯酰甘氨酸是 GPR18 受体的完全激动剂，可诱导人子宫内膜 HEC-1B 细胞迁移。
Br J Pharmacol. 2012 Apr;165(8):2414-24. doi: 10.1111/j.1476-5381.2011.01497.x.
2
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.国际基础和临床药理学联合会. LXXIX. 大麻素受体及其配体：超越 CB₁ 和 CB₂。
Pharmacol Rev. 2010 Dec;62(4):588-631. doi: 10.1124/pr.110.003004.
3
Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target.G 蛋白偶联受体（GPCRs）在转移性黑色素瘤中的定量表达谱分析：作为新型药物靶点的组成性激活孤儿 GPCR GPR18。
Pigment Cell Melanoma Res. 2011 Feb;24(1):207-18. doi: 10.1111/j.1755-148X.2010.00781.x. Epub 2010 Oct 21.
4
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.N-花生四烯酰甘氨酸是一种丰富的内源性脂质，通过假定的异常大麻素受体 GPR18 强烈驱动定向细胞迁移。
BMC Neurosci. 2010 Mar 26;11:44. doi: 10.1186/1471-2202-11-44.
5
T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.T型钙通道抑制是内源性脂氨基酸镇痛作用的基础。
J Neurosci. 2009 Oct 21;29(42):13106-14. doi: 10.1523/JNEUROSCI.2919-09.2009.
6
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.内源性大麻素花生四烯乙醇胺通过两条不同途径作为信号脂质N-花生四烯酰甘氨酸的前体。
BMC Biochem. 2009 May 21;10:14. doi: 10.1186/1471-2091-10-14.
7
Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.GPR92/LPA5溶血磷脂酸受体独特的配体选择性表明其在人血小板激活中的作用。
J Biol Chem. 2009 Jun 19;284(25):17304-17319. doi: 10.1074/jbc.M109.003194. Epub 2009 Apr 14.
8
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.使用β-抑制蛋白PathHunter检测法鉴定脂质G蛋白偶联受体配体
J Biol Chem. 2009 May 1;284(18):12328-38. doi: 10.1074/jbc.M806516200. Epub 2009 Mar 13.
9
Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92.法尼基焦磷酸酯和N-花生四烯酰甘氨酸作为GPR92内源性配体的鉴定。
J Biol Chem. 2008 Jul 25;283(30):21054-64. doi: 10.1074/jbc.M708908200. Epub 2008 May 22.
10
Cytochrome c catalyzes the in vitro synthesis of arachidonoyl glycine.细胞色素c催化花生四烯酰甘氨酸的体外合成。
Biochem Biophys Res Commun. 2008 Jan 11;365(2):322-7. doi: 10.1016/j.bbrc.2007.10.175. Epub 2007 Nov 5.