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小胶质细胞中的 GPR18:对中枢神经系统和内源性大麻素系统信号转导的影响。

GPR18 in microglia: implications for the CNS and endocannabinoid system signalling.

机构信息

Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47408, USA.

出版信息

Br J Pharmacol. 2012 Dec;167(8):1575-82. doi: 10.1111/j.1476-5381.2012.02019.x.

DOI:10.1111/j.1476-5381.2012.02019.x
PMID:22563843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3525861/
Abstract

A review of what is presently known about the G protein coupled receptor GPR18 in terms of its expression and distribution, pharmacology and potential implications for central nervous system and endocannabinoid system signalling. LINKED ARTICLES This article is part of a themed section on Cannabinoids. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.167.issue-8.

摘要

综述了目前已知的 G 蛋白偶联受体 GPR18 在表达和分布、药理学方面的知识,以及其对中枢神经系统和内源性大麻素系统信号传递的潜在影响。

相关文章 本文是关于大麻素的专题部分的一部分。要查看本部分中的其他文章,请访问 http://dx.doi.org/10.1111/bph.2012.167.issue-8。

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本文引用的文献

1
N-arachidonoyl glycine induces macrophage apoptosis via GPR18.N-花生四烯酰甘氨酸通过 GPR18 诱导巨噬细胞凋亡。
Biochem Biophys Res Commun. 2012 Feb 10;418(2):366-71. doi: 10.1016/j.bbrc.2012.01.027. Epub 2012 Jan 11.
2
So what do we call GPR18 now?那么,我们现在应该如何称呼 GPR18 呢?
Br J Pharmacol. 2012 Apr;165(8):2411-3. doi: 10.1111/j.1476-5381.2011.01731.x.
3
Resolution of inflammation by N-arachidonoylglycine.通过 N-花生四烯酰基甘氨酸来缓解炎症。
J Cell Biochem. 2011 Nov;112(11):3227-33. doi: 10.1002/jcb.23245.
4
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.Δ(9)-四氢大麻酚和 N-花生四烯酰甘氨酸是 GPR18 受体的完全激动剂,可诱导人子宫内膜 HEC-1B 细胞迁移。
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5
Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells.暴露于大麻素大麻二酚和 Δ9-四氢大麻酚在 BV-2 小胶质细胞中介导的差异转录谱。
Br J Pharmacol. 2012 Apr;165(8):2512-28. doi: 10.1111/j.1476-5381.2011.01461.x.
6
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂.国际基础和临床药理学联合会. LXXIX. 大麻素受体及其配体:超越 CB₁ 和 CB₂。
Pharmacol Rev. 2010 Dec;62(4):588-631. doi: 10.1124/pr.110.003004.
7
Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target.G 蛋白偶联受体(GPCRs)在转移性黑色素瘤中的定量表达谱分析:作为新型药物靶点的组成性激活孤儿 GPCR GPR18。
Pigment Cell Melanoma Res. 2011 Feb;24(1):207-18. doi: 10.1111/j.1755-148X.2010.00781.x. Epub 2010 Oct 21.
8
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.N-花生四烯酰甘氨酸是一种丰富的内源性脂质,通过假定的异常大麻素受体 GPR18 强烈驱动定向细胞迁移。
BMC Neurosci. 2010 Mar 26;11:44. doi: 10.1186/1471-2202-11-44.
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Novel endogenous N-acyl glycines identification and characterization.新型内源性N-酰基甘氨酸的鉴定与表征。
Vitam Horm. 2009;81:191-205. doi: 10.1016/S0083-6729(09)81008-X.
10
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals.静息态小胶质细胞在体内直接监测突触的功能状态,并决定缺血性终末的命运。
J Neurosci. 2009 Apr 1;29(13):3974-80. doi: 10.1523/JNEUROSCI.4363-08.2009.