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2008年法国与富马酸二甲酯相关的皮炎暴发的流行病学描述

Epidemiological description of an outbreak of dermatitis related to dimethylfumarate, France, 2008.

作者信息

Lefranc Agnès, Flesch Françoise, Cochet Amandine, Daoudi Jamel, Crinier Raphaël

机构信息

French Institute for Public Health Surveillance (InVS), 12 rue du Val d'Osne, Saint Maurice cédex, France.

出版信息

Arch Environ Occup Health. 2011;66(4):217-22. doi: 10.1080/19338244.2011.564228.

Abstract

Following similar events in other European countries, some cases of dermatitis related to contact with China-imported furniture possibly treated with dimethyl(E)-butenedioate (dimethylfumarate [DMF]) were reported to the French institute for public health surveillance at the beginning of September 2008. An active multisource case collection was conducted in order to provide an epidemiological description of this outbreak. Results of this investigation show that, in France, mainly during the 4th quarter of 2008, a large number of people presented dermatological symptoms at least plausibly due to a contact with DMF-treated consumer products. The products involved were mostly shoes and sofa (94% of cases). This work offers an example of a multipartner investigation in the field of environmental health. It also shows how the results obtained contributed to decision-making and resulted in the limitation of DMF-treated products in France and in Europe.

摘要

继其他欧洲国家发生类似事件后,2008年9月初,法国公共卫生监测机构收到一些与接触从中国进口的、可能用(E)-丁烯二酸二甲酯(富马酸二甲酯[DMF])处理过的家具有关的皮炎病例报告。为了对此次疫情进行流行病学描述,开展了积极的多渠道病例收集工作。这项调查结果显示,在法国,主要是在2008年第四季度,大量民众出现了至少看似与接触经DMF处理的消费品有关的皮肤症状。所涉产品主要是鞋子和沙发(占病例的94%)。这项工作为环境卫生领域的多方合作调查提供了一个范例。它还展示了所获结果如何为决策提供依据,并导致法国和欧洲对经DMF处理的产品加以限制。

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