Hainan Key Laboratory of Tropical Microbe Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences & Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Haikou 571101, China.
Hainan Provincial Key Laboratory of Tropical Maricultural Technologies, Hainan Academy of Ocean and Fisheries Sciences, Haikou 571126, China.
Molecules. 2023 Jun 30;28(13):5138. doi: 10.3390/molecules28135138.
Marine natural products have been recognized as the most promising source of bioactive substances for drug discovery research. This review illustrates the diversity of culturable actinobacteria associated with marine algae, their bioactivity and metabolites, and approaches to their isolation and determination of their biological properties. Furthermore, actinobacteria associated with marine algae are presented as a new subject for an extensive investigation to find novel and active natural products, which make them a potentially rich and innovative source for new drug development deserving more attention and exploration.
海洋天然产物已被公认为药物发现研究中最有前途的生物活性物质来源。本综述说明了与海洋藻类相关的可培养放线菌的多样性、它们的生物活性和代谢产物，以及它们的分离和生物特性测定方法。此外，与海洋藻类相关的放线菌被认为是一个广泛研究的新课题，以寻找新型和有效的天然产物，使它们成为新药开发的潜在丰富和创新来源，值得更多关注和探索。
