Caplan G A, Brigham B A
Department of Medical Oncology Prince of Wales Hospital, Randwick, Australia.
Cancer. 1990 Sep 1;66(5):1005-6. doi: 10.1002/1097-0142(19900901)66:5<1005::aid-cncr2820660535>3.0.co;2-h.
There is considerable theoretical evidence that marijuana should be carcinogenic. However, most reviews have found no direct evidence of chronic marijuana smoking causing lung cancer. Some recent reports implicate marijuana smoking as a cause of cancer of the upper aerodigestive tract, though most of the subjects were exposed to other, possibly confounding, etiologic factors, namely tobacco and alcohol. We report two cases of squamous cell carcinoma of the tongue in men who chronically smoked marijuana but had no other risk factors. The totality of cases may point to a predilection of marijuana smoke for carcinogenesis in the upper aerodigestive tract. This correlates with nonmalignant effects and may be related to a different method of smoking marijuana compared with tobacco.
有大量理论证据表明大麻具有致癌性。然而，大多数综述并未发现长期吸食大麻会导致肺癌的直接证据。近期一些报告暗示吸食大麻是上呼吸道消化道癌症的一个病因，不过大多数研究对象还接触了其他可能具有混淆作用的病因，即烟草和酒精。我们报告了两例男性舌鳞状细胞癌病例，他们长期吸食大麻但无其他风险因素。这些病例总体情况可能表明大麻烟雾易于在上呼吸道消化道引发癌变。这与非恶性影响相关，并且可能与吸食大麻和烟草的方式不同有关。
