Laboratory for Epigenetics and Molecular Medicine, Department of Medical Biology, University of Zagreb Medical School, Zagreb, Croatia.
Cancer Epidemiol. 2012 Feb;36(1):11-5. doi: 10.1016/j.canep.2011.09.010. Epub 2011 Oct 20.
Testicular cancer, although a rare malignancy, represents the most common cancer in young male populations of Western origin. While increasing incidence trends of testicular cancer have been reported, mortality is declining in many high-resource settings. Using national data from the Croatian National Cancer Registry for the period 1983-2007, time trends were analysed by joinpoint regression and Age-Period-Cohort models. The present study is the first to analyse the testicular cancer trends in the Croatian population. Over the 25-year period, a mean number of 89 incident cases and 13 deaths were reported annually. The observed mean annual increases in age-standardised rates were 7.0% for incidence and 1.6% for mortality, with no abrupt linear changes (joinpoints) identified. The incidence rates of testicular cancer incidence have been steeply increasing in successive cohorts born since the mid-1930s. The rapid rise in testicular cancer incidence in the Croatian population appears to be one of the highest rates of increase recorded in Europe and worldwide. The lack of decline in the mortality rates over time, while based on relatively few deaths, highlights a need for improvements in diagnostics and management of therapy in Croatia in order to improve the survival and quality-of-life of testicular cancer patients.
睾丸癌虽然是一种罕见的恶性肿瘤，但却是西方起源的年轻男性群体中最常见的癌症。尽管有报道称睾丸癌的发病率呈上升趋势，但在许多高资源环境中，死亡率正在下降。本研究利用 1983-2007 年期间克罗地亚国家癌症登记处的全国数据，通过联合点回归和年龄-时期-队列模型分析时间趋势。本研究首次分析了克罗地亚人群中睾丸癌的趋势。在 25 年期间，每年报告平均 89 例发病和 13 例死亡。观察到的发病率和死亡率的年平均增长率分别为 7.0%和 1.6%，没有明显的线性变化（联合点）。自 20 世纪 30 年代中期以来，出生于连续队列的人群中睾丸癌的发病率一直在急剧上升。克罗地亚人群中睾丸癌发病率的快速上升似乎是欧洲和全球记录的最高增长率之一。死亡率随时间的推移没有下降，尽管死亡人数相对较少，但强调了克罗地亚需要改进诊断和治疗管理，以提高睾丸癌患者的生存率和生活质量。
