Research and Development Centre, Bharathiar University, Coimbatore - 646 041, Tamil Nadu, India.
Asian Pac J Trop Med. 2011 Oct;4(10):778-85. doi: 10.1016/S1995-7645(11)60193-4.
To investigate antidiabetic efficacy of the extract of field grown and in vitro raised leaves of Solanum xanthocarpum (S. xanthocarpum) against alloxan induced diabetic rats.
The antidiabetic activity of the crude methanol extracts of the field grown and in vitro raised leaves of S. xanthocarpum at different concentrations (100-200 mg/kg bw) was tested against alloxan induced diabetic rats. The antidiabetic efficacy was validated through various biochemical parameters and the antioxidant effect was also determined. The phytochemical analyses of field grown S. xanthocarpum and in vitro rasied S. xanthocarpum leaves were done by estimating their chlorophyll, carotenoids, total sugar, protein, amino acid and minerals contents.
The results revealed that the methanol extracts of both the leaves (field grown and in vitro raised) of S. xanthocarpum was efficient anti hyperglycemic agents at a concentration of 200 mg/kg bw and posses potent antioxidant activity. However, the extracts of in vitro rasied S. xanthocarpum raised leaves exhibit higher efficacy than the field grown leaves in all tested concentrations. Proximal composition and mineral analysis of S. xanthocarpum revealed higher concentration of contents in in vitro rasied S. xanthocarpum than field grown S. xanthocarpum.
From the results it can be concluded that the leaves extracts of S. xanthocarpum can be a potential candidate in treating the hyperglycemic conditions and suits to be an agent to reduce oxidative stress.
研究田间生长和体外培养的茄叶提取物对链脲佐菌素诱导糖尿病大鼠的降血糖作用。
用不同浓度（100-200mg/kg bw）的田间生长和体外培养的茄叶粗甲醇提取物对链脲佐菌素诱导的糖尿病大鼠进行降血糖活性测试。通过各种生化参数验证降血糖效果，并测定抗氧化效果。通过测定田间生长的茄和体外培养的茄叶的叶绿素、类胡萝卜素、总糖、蛋白质、氨基酸和矿物质含量来进行植物化学分析。
结果表明，茄叶（田间生长和体外培养）的甲醇提取物在 200mg/kg bw 的浓度下是有效的抗高血糖剂，并具有很强的抗氧化活性。然而，在所有测试浓度下，体外培养的茄叶提取物的功效都高于田间生长的茄叶。对茄的近侧成分和矿物质分析表明，体外培养的茄中各成分的含量均高于田间生长的茄。
从结果可以得出结论，茄叶提取物可以成为治疗高血糖症的潜在候选药物，适合作为降低氧化应激的药物。
