Miravitlles Marc, Llor Carles, Calvo Eduardo, Diaz Silvia, Díaz-Cuervo Helena, Gonzalez-Rojas Nuria
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Ciber de Enfermedades Respiratorias (CIBERES), Hospital Clínic, Barcelona, España.
Med Clin (Barc). 2012 Nov 17;139(12):522-30. doi: 10.1016/j.medcli.2011.06.022. Epub 2011 Oct 19.
The chronic obstructive pulmonary disease (COPD) is a highly undiagnosed disease. The use of short screening questionnaires designed to detect chronic airflow obstruction may help to the early diagnosis of COPD.
This was an observational, cross-sectional epidemiological study aimed to validate the translated into Spanish version of the COPD-PS questionnaire. Socio-demographic and clinical data of participants were collected, as well as their answers to the COPD-PS and EQ-5D questionnaires. The ratio FEV(1)/FEV(6) was measured with the COPD-6 device. The psychometric properties of the questionnaire and the diagnostic yield of the FEV(1)/FEV(6) ratio were analysed, both referred to the gold standard of post-bronchodilator FEV(1)/FVC < 0.7.
Ten primary care centers participated in the study and included 94 controls and 79 cases with chronic airflow obstruction. Questionnaire characteristics were: feasibility, 2.3% of participants did not answer at least one item; mean time to fill the questionnaire was 47.7 seconds; 4.7% of individuals had a 0 score. Validity, moderate correlation with EQ-5D scores and moderate-high with FEV(1); the scores of COPD-PS were related to all parameters associated with COPD. A cut off of 4 units had the best sensitivity/specificity ratio and correctly classified 78% of participants. For the FEV(1)/FEV(6) ratio, a cut off of 0.75 correctly classified 85% of individuals.
The COPD-PS questionnaire demonstrated good psychometric properties. A cut off score of 4 has excellent predictive value. A ratio of 0.75 in the FEV(1)/FEV(6) provides an excellent correlation with the ratio FEV(1)/FVC and is useful for the identification of individuals with chronic airflow obstruction.
慢性阻塞性肺疾病（COPD）是一种极易被漏诊的疾病。使用旨在检测慢性气流受限的简短筛查问卷可能有助于COPD的早期诊断。
这是一项观察性横断面流行病学研究，旨在验证翻译成西班牙语版本的COPD-PS问卷。收集了参与者的社会人口统计学和临床数据，以及他们对COPD-PS和EQ-5D问卷的回答。使用COPD-6设备测量FEV(1)/FEV(6)比值。分析了问卷的心理测量特性以及FEV(1)/FEV(6)比值的诊断效能，两者均参照支气管扩张剂后FEV(1)/FVC<0.7的金标准。
10个初级保健中心参与了该研究，纳入了94名对照者和79例慢性气流受限患者。问卷特征如下：可行性方面，2.3%的参与者至少有一项未作答；填写问卷的平均时间为47.7秒；4.7%的个体得分为0分。效度方面，与EQ-5D评分呈中度相关，与FEV(1)呈中度至高度相关；COPD-PS的评分与所有COPD相关参数有关。截断值为4分时具有最佳的灵敏度/特异度比，正确分类了78%的参与者。对于FEV(1)/FEV(6)比值，截断值为0.75时正确分类了85%的个体。
COPD-PS问卷显示出良好的心理测量特性。截断分数为4具有出色的预测价值。FEV(1)/FEV(6)比值为0.75与FEV(1)/FVC比值具有良好的相关性，有助于识别慢性气流受限个体。
