Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy.
Crit Rev Oncol Hematol. 2012 Jul;83(1):71-83. doi: 10.1016/j.critrevonc.2011.09.003. Epub 2011 Oct 19.
Several clinical-pathological parameters have been related to survival of patients with invasive squamous cell carcinoma of the vulva, whereas few studies have investigated the ability of biological variables to predict the clinical outcome of these patients. The present paper reviews the literature data on the prognostic relevance of lymph node-related parameters, primary tumor-related parameters, FIGO stage, blood variables, and tissue biological variables. Regarding these latter, the paper takes into account the analysis of DNA content, cell cycle-regulatory proteins, apoptosis-related proteins, epidermal growth factor receptor [EGFR], and proteins that are involved in tumor invasiveness, metastasis and angiogenesis. At present, the lymph node status and FIGO stage according to the new 2009 classification system are the main predictors for vulvar squamous cell carcinoma, whereas biological variables do not have yet a clinical relevance and their role is still investigational.
一些临床病理参数与外阴浸润性鳞状细胞癌患者的生存有关，而很少有研究调查生物变量预测这些患者临床结局的能力。本文综述了关于淋巴结相关参数、原发肿瘤相关参数、FIGO 分期、血液变量和组织生物学变量的预后相关性的文献数据。关于后者，本文考虑了 DNA 含量、细胞周期调节蛋白、凋亡相关蛋白、表皮生长因子受体 [EGFR] 以及参与肿瘤侵袭、转移和血管生成的蛋白的分析。目前，根据新的 2009 年分类系统的淋巴结状态和 FIGO 分期是外阴鳞状细胞癌的主要预测因子，而生物变量尚未具有临床相关性，其作用仍在研究中。
