Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy;
Department of New Technologies and Translational Research, Division of Pathology, University of Pisa, Pisa, Italy.
In Vivo. 2021 Mar-Apr;35(2):1051-1056. doi: 10.21873/invivo.12349.
BACKGROUND/AIM: The aims of the study were: i) to assess the incidence of perineural invasion (PNI) in squamous cell carcinoma of the vulva and ii) to correlate PNI with common pathological prognostic variables and clinical outcome of patients.
The hospital records of 64 patients with vulvar squamous cell carcinoma who underwent primary radical surgery were reviewed.
PNI was significantly related to stage (p=0.038), size (p=0.038), lymph-vascular space involvement (p=0.013) and nodal status (p=0.038), but not to patient age, tumor grade and stromal invasion. Five-year disease-free survival was 30.0% in patients with PNI and 53.1% in those without PNI (p=0.018), and the corresponding 5-year overall survival was 50.0% and 77.1% (p=0.031), respectively.
PNI was associated with common pathological prognostic variables and with a poorer clinical outcome in patients with vulvar squamous cell carcinoma.
背景/目的：本研究的目的为：i）评估外阴鳞癌中神经周围侵犯（PNI）的发生率，ii）分析 PNI 与常见病理预后变量及患者临床结局的相关性。
回顾性分析了 64 例行根治性手术的外阴鳞癌患者的医院病历。
PNI 与分期（p=0.038）、肿瘤大小（p=0.038）、淋巴管血管间隙浸润（p=0.013）和淋巴结状态（p=0.038）显著相关，而与患者年龄、肿瘤分级和间质浸润无关。PNI 阳性患者的 5 年无病生存率为 30.0%，阴性患者为 53.1%（p=0.018），相应的 5 年总生存率分别为 50.0%和 77.1%（p=0.031）。
PNI 与外阴鳞癌患者的常见病理预后变量及临床结局不良相关。
