福斯曼抗原衍生物的合成及其在结合疫苗中的应用。
Synthesis of a Forssman antigen derivative for use in a conjugate vaccine.
机构信息
Alberta Ingenuity Center for Carbohydrate Science, Department of Chemistry, University of Calgary, Calgary AB, Canada T2N 1N4.
出版信息
Carbohydr Res. 2011 Dec 13;346(17):2650-62. doi: 10.1016/j.carres.2011.09.015. Epub 2011 Sep 29.
PMID:22015168
Abstract
The total chemical synthesis of a Forssman antigen analog is described. The pentasaccharide contains a functionalized tether which should facilitate future conjugation with immunogenic proteins. We found that the total synthesis can be efficiently achieved by following a convergent 2+3 strategy, and using N-Troc protected GalNAc thioglycoside as a donor.
摘要
本文描述了 Forssman 抗原类似物的全化学合成。该五糖含有一个功能化的连接臂，这应该有助于未来与免疫原性蛋白的偶联。我们发现，通过采用收敛的 2+3 策略，并使用 N-Troc 保护的 GalNAc 硫糖苷作为供体，可以有效地实现全合成。
Zotero 插件