结核分枝杆菌“北京”株流行：一场与突变的赛跑？
Mycobacterium tuberculosis "Beijing" epidemics: a race against mutations?
机构信息
The Foundation For Medical Research, 84-A, R.G.Thadani Marg, Worli, Mumbai 400018, India.
出版信息
Tuberculosis (Edinb). 2012 Jan;92(1):92-4. doi: 10.1016/j.tube.2011.09.004. Epub 2011 Oct 19.
PMID:22015174
Abstract
Multi Drug Resistant Tuberculosis Beijing strains exhibit different drug-resistance mutations (DRM) in different locations. By comparing DRM in Beijing reported from Tuberculosis endemic and epidemic locations, we propose that DRM selected in a population cannot tolerate biologically available drugs in different populations resulting in further evolution through novel DRM.
摘要
耐多药结核北京株在不同的位置存在不同的耐药突变（DRM）。通过比较来自结核病流行和高发地区的北京株报告的 DRM，我们提出在一个人群中选择的 DRM 在不同人群中不能耐受生物利用的药物，从而导致通过新的 DRM 进一步进化。
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