Division of Molecular Biology and Human Genetics, Department of Biomedical Science, Stellenbosch University, Tygerberg, South Africa.
Int J Tuberc Lung Dis. 2010 Jan;14(1):119-21.
Temporal analysis of drug-resistant tuberculosis (TB) cases in the Western Cape, South Africa, showed a 1.5-fold increase over a 2-year period, suggesting a doubling time of 8.2 years. This increase was strongly associated with multidrug resistance and the Beijing genotype. Forty-two per cent of the overall increase was due to the Beijing genotype strain R220, suggesting that this strain had evolved unique properties that allowed for both acquisition and transmission of drug resistance. To curb the drug-resistant TB epidemic in this setting, it will be essential to implement rapid diagnostics and efficient infection control measures, improve contact screening and ensure treatment adherence.
南非西开普省耐药结核病（TB）病例的时间分析显示，在两年内增加了 1.5 倍，表明倍增时间为 8.2 年。这种增加与耐多药和北京基因型强烈相关。整体增加的 42%归因于北京基因型菌株 R220，这表明该菌株具有独特的特性，既可以获得又可以传播耐药性。为了遏制该环境中的耐药性结核病流行，实施快速诊断和有效的感染控制措施、改善接触筛查并确保治疗依从性至关重要。
