小分子 GTP 酶对 G 蛋白偶联受体正向转运的调节。
Small GTPase regulation of GPCR anterograde trafficking.
机构信息
Institute of Respiratory Diseases, Second Affiliated Hospital of the Third Military Medical University, Chongqing 400037, China.
出版信息
Trends Pharmacol Sci. 2012 Jan;33(1):28-34. doi: 10.1016/j.tips.2011.09.002. Epub 2011 Oct 17.
Abstract
The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis and recycling. By contrast, the molecular mechanisms underlying anterograde transport of newly synthesized GPCRs from the endoplasmic reticulum (ER) to the cell surface have only now begun to be revealed. In this review we discuss current advances in understanding the role of Ras-like GTPases, specifically the Rab and Sar1/ARF subfamilies, in regulating cell-surface transport of GPCRs en route from the ER and the Golgi.
摘要
三聚体 G 蛋白偶联受体（GPCRs）的生理功能取决于其细胞内运输和精确靶向功能目的地。在过去的几十年中，大多数关于 GPCR 运输的研究都集中在内吞作用和回收涉及的事件上。相比之下，新合成的 GPCR 从内质网（ER）到细胞表面的顺行运输的分子机制才刚刚开始被揭示。在这篇综述中，我们讨论了当前在理解 Ras 样 GTP 酶（特别是 Rab 和 Sar1/ARF 亚家族）在调节 GPCR 从 ER 和高尔基体到细胞表面运输过程中的作用方面的进展。
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