纳米医学在动脉粥样硬化管理中的观点和机遇。
Perspectives and opportunities for nanomedicine in the management of atherosclerosis.
机构信息
Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, BOX 1234, New York 10029, USA.
出版信息
Nat Rev Drug Discov. 2011 Oct 21;10(11):835-52. doi: 10.1038/nrd3578.
Abstract
The use of nanotechnology for medical purposes--nanomedicine--has grown exponentially over the past few decades. This is exemplified by the US Food and Drug Administration's approval of several nanotherapies for various conditions, as well as the funding of nanomedical programmes worldwide. Although originally the domain of anticancer therapy, recent advances have illustrated the considerable potential of nanomedicine in the diagnosis and treatment of atherosclerosis. This Review elaborates on nanoparticle-targeting concepts in atherosclerotic disease, provides an overview of the use of nanomedicine in atherosclerosis, and discusses potential future applications and clinical benefits.
摘要
在过去几十年中，纳米技术在医疗领域的应用——纳米医学——呈指数级增长。美国食品和药物管理局 (FDA) 批准了几种用于各种疾病的纳米疗法，以及全球范围内对纳米医学项目的资助，就是这一趋势的例证。尽管纳米医学最初是癌症治疗领域的专属领域，但最近的进展表明，纳米医学在动脉粥样硬化的诊断和治疗方面具有巨大的潜力。本文详细阐述了纳米颗粒在动脉粥样硬化疾病中的靶向作用概念，概述了纳米医学在动脉粥样硬化中的应用，并讨论了其潜在的未来应用和临床获益。
相似文献
1
Perspectives and opportunities for nanomedicine in the management of atherosclerosis.纳米医学在动脉粥样硬化管理中的观点和机遇。
Nat Rev Drug Discov. 2011 Oct 21;10(11):835-52. doi: 10.1038/nrd3578.
2
Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications.刺激响应型纳米抗癌药物输送系统在系统应用中的新兴潜力。
Arch Pharm Res. 2018 Feb;41(2):111-129. doi: 10.1007/s12272-017-0995-x. Epub 2017 Dec 6.
3
Nanomedicine-based neuroprotective strategies in patient specific-iPSC and personalized medicine.基于纳米医学的针对患者特异性诱导多能干细胞及个性化医疗的神经保护策略。
Int J Mol Sci. 2014 Mar 4;15(3):3904-25. doi: 10.3390/ijms15033904.
4
Nanomedicine-based strategies for treatment of atherosclerosis.基于纳米医学的动脉粥样硬化治疗策略。
Trends Mol Med. 2014 May;20(5):271-81. doi: 10.1016/j.molmed.2013.12.001. Epub 2014 Mar 1.
5
Nanomedicine--prospective therapeutic and diagnostic applications.纳米医学——前瞻性治疗与诊断应用
Expert Opin Biol Ther. 2005 Jan;5(1):1-5. doi: 10.1517/14712598.5.1.1.
6
Targeting and therapeutic peptides in nanomedicine for atherosclerosis.纳米医学中用于动脉粥样硬化的靶向和治疗性肽
Exp Biol Med (Maywood). 2016 May;241(9):891-8. doi: 10.1177/1535370216640940. Epub 2016 Mar 27.
7
Emerging nanomedicines for early cancer detection and improved treatment: current perspective and future promise.新兴纳米药物在癌症早期检测和治疗改善方面的应用：当前的视角和未来的前景。
Pharmacol Ther. 2010 Nov;128(2):324-35. doi: 10.1016/j.pharmthera.2010.07.007. Epub 2010 Aug 10.
8
The emerging applications of magnetic nanovectors in nanomedicine.磁性纳米载体在纳米医学中的新兴应用。
Pharm Pat Anal. 2015;4(4):285-304. doi: 10.4155/ppa.15.17.
9
The upcoming field of theranostic nanomedicine: an overview.治疗诊断纳米医学的新兴领域：概述。
J Biomed Nanotechnol. 2012 Dec;8(6):859-82. doi: 10.1166/jbn.2012.1459.
10
Nanomedicine for the prevention, treatment and imaging of atherosclerosis.用于动脉粥样硬化的预防、治疗和成像的纳米医学。
Nanomedicine. 2012 Sep;8 Suppl 1:S59-68. doi: 10.1016/j.nano.2012.05.006. Epub 2012 May 26.
引用本文的文献
1
A programmable platelet theranostic platform for adaptive multi-stage delivery and synergistic immunotherapy in atherosclerosis.一种用于动脉粥样硬化中适应性多阶段递送和协同免疫治疗的可编程血小板诊疗平台。
Nat Commun. 2025 Jul 11;16(1):6445. doi: 10.1038/s41467-025-61789-9.
2
SERS and colorimetric dual-mode detection of cholesterol during drug treatment of atherosclerosis.动脉粥样硬化药物治疗期间胆固醇的表面增强拉曼光谱和比色双模式检测
Anal Bioanal Chem. 2025 May 22. doi: 10.1007/s00216-025-05910-3.
3
Key parameters for designing robust 2D and 3D spheroid models for atherosclerosis research.用于动脉粥样硬化研究的稳健二维和三维球体模型设计的关键参数。
Bioeng Transl Med. 2025 Mar 21;10(3):e10736. doi: 10.1002/btm2.10736. eCollection 2025 May.
4
Recent progress in ROS-responsive biomaterials for the diagnosis and treatment of cardiovascular diseases.用于心血管疾病诊断与治疗的活性氧响应性生物材料的最新进展
Theranostics. 2025 Apr 11;15(11):5172-5219. doi: 10.7150/thno.106991. eCollection 2025.
5
High-Density Lipoprotein Biomimetic Inorganic-Organic Composite Nanosystem for Atherosclerosis Therapy.用于动脉粥样硬化治疗的高密度脂蛋白仿生无机-有机复合纳米系统
Polymers (Basel). 2025 Feb 26;17(5):625. doi: 10.3390/polym17050625.
6
Single chain fragment variable, a new theranostic approach for cardiovascular diseases.单链可变片段，一种用于心血管疾病的新型诊疗方法。
Front Immunol. 2024 Dec 13;15:1443290. doi: 10.3389/fimmu.2024.1443290. eCollection 2024.
7
Lipoic Acid Nanoparticles Exert Effective Antiatherosclerosis Effects through Anti-Inflammatory and Antioxidant Pathways.硫辛酸纳米颗粒通过抗炎和抗氧化途径发挥有效的抗动脉粥样硬化作用。
ACS Omega. 2024 Nov 25;9(49):48642-48649. doi: 10.1021/acsomega.4c07745. eCollection 2024 Dec 10.
8
Nanomaterials for stroke diagnosis and treatment.用于中风诊断和治疗的纳米材料。
iScience. 2024 Oct 9;27(11):111112. doi: 10.1016/j.isci.2024.111112. eCollection 2024 Nov 15.
9
Nanomedicine-based strategies for the treatment of vein graft disease.基于纳米医学的静脉移植物疾病治疗策略。
Nat Rev Cardiol. 2025 Apr;22(4):255-272. doi: 10.1038/s41569-024-01094-y. Epub 2024 Nov 5.
10
Emerging Trends and Innovations in the Treatment and Diagnosis of Atherosclerosis and Cardiovascular Disease: A Comprehensive Review towards Healthier Aging.动脉粥样硬化与心血管疾病治疗和诊断的新趋势与创新：迈向健康老龄化的全面综述
Pharmaceutics. 2024 Aug 3;16(8):1037. doi: 10.3390/pharmaceutics16081037.
本文引用的文献
1
Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.葡聚糖包覆的氧化铁纳米颗粒：一种用于靶向分子成像、分子诊断和治疗的多功能平台。
Acc Chem Res. 2011 Oct 18;44(10):842-52. doi: 10.1021/ar200084x. Epub 2011 Jun 10.
2
Thrombin-inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute thrombosis.凝血酶抑制型全氟碳纳米颗粒为急性血栓的治疗和磁共振成像提供了一种新策略。
J Thromb Haemost. 2011 Jul;9(7):1292-300. doi: 10.1111/j.1538-7836.2011.04339.x.
3
Progress and challenges in translating the biology of atherosclerosis.动脉粥样硬化生物学翻译的进展与挑战。
Nature. 2011 May 19;473(7347):317-25. doi: 10.1038/nature10146.
4
Report of the National Heart, Lung, and Blood Institute working group on the translation of cardiovascular molecular imaging.美国国立心肺血液研究所心血管分子成像翻译工作组报告
Circulation. 2011 May 17;123(19):2157-63. doi: 10.1161/CIRCULATIONAHA.110.000943.
5
Coronary atherosclerosis imaging by coronary CT angiography: current status, correlation with intravascular interrogation and meta-analysis.冠状动脉 CT 血管成像在冠状动脉粥样硬化中的应用：现状、与血管内检查的相关性及荟萃分析。
JACC Cardiovasc Imaging. 2011 May;4(5):537-48. doi: 10.1016/j.jcmg.2011.03.006.
6
Anti-inflammatory therapeutics for the treatment of atherosclerosis.抗动脉粥样硬化炎症治疗策略。
Nat Rev Drug Discov. 2011 May;10(5):365-76. doi: 10.1038/nrd3444.
7
Immunosuppressive therapy with oral prednisone to prevent restenosis after PCI. A multicenter randomized trial.经皮冠状动脉介入治疗（PCI）后口服泼尼松抑制免疫治疗预防再狭窄：一项多中心随机试验。
Am J Med. 2011 May;124(5):434-43. doi: 10.1016/j.amjmed.2010.11.027.
8
Microfabrication and nanotechnology in stent design.支架设计中的微加工和纳米技术。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 May-Jun;3(3):256-68. doi: 10.1002/wnan.123. Epub 2011 Jan 31.
9
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins.微小 RNA 经血浆运输，并通过高密度脂蛋白递送至受体细胞。
Nat Cell Biol. 2011 Apr;13(4):423-33. doi: 10.1038/ncb2210. Epub 2011 Mar 20.
10
The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents.人类冠状动脉植入物中金属裸支架和药物洗脱支架的新生动脉粥样硬化的病理学。
J Am Coll Cardiol. 2011 Mar 15;57(11):1314-22. doi: 10.1016/j.jacc.2011.01.011.
Zotero 插件