用于中风诊断和治疗的纳米材料。

Nanomaterials for stroke diagnosis and treatment.

作者信息

Liu Yang, Li Junying, Guo Huaijuan, Fang Chao, Yang Qiaoling, Qin Wen, Wang Hai, Xian Yong, Yan Xuebing, Yin Binxu, Zhang Kun

机构信息

Department of Oncology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.

Department of Pharmacy and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu 610072, China.

出版信息

iScience. 2024 Oct 9;27(11):111112. doi: 10.1016/j.isci.2024.111112. eCollection 2024 Nov 15.

DOI:10.1016/j.isci.2024.111112

PMID:39502285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11536039/

Abstract

Nanomaterials and nanotechnology innovations possess unique physicochemical properties that present new opportunities in the realm of stroke detection, diagnosis, and treatment. This comprehensive review explores the utilization of nanomaterials in the diagnosis and treatment of strokes, encompassing recent advancements in computed tomography (CT), magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as groundbreaking applications of nanomaterials and bionanomaterials in drug delivery systems and brain tissue repair. Additionally, this review meticulously examines significant challenges such as biocompatibility toxicity and long-term safety, proposing potential strategies to surmount these obstacles. Moreover, this review delves into the application of nanomaterials to improve the clinical diagnosis of stroke patients, elucidates the potential of nanotechnology in post-stroke therapy, and identifies future research directions and potential clinical applications.

摘要

纳米材料和纳米技术创新具有独特的物理化学性质，为中风的检测、诊断和治疗领域带来了新机遇。这篇综述全面探讨了纳米材料在中风诊断和治疗中的应用，涵盖计算机断层扫描（CT）、磁共振成像（MRI）和磁粒子成像（MPI）的最新进展，以及纳米材料和生物纳米材料在药物递送系统和脑组织修复中的突破性应用。此外，本综述还仔细研究了生物相容性毒性和长期安全性等重大挑战，提出了克服这些障碍的潜在策略。此外，本综述深入探讨了纳米材料在改善中风患者临床诊断方面的应用，阐明了纳米技术在中风后治疗中的潜力，并确定了未来的研究方向和潜在的临床应用。