Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi, UP, India.
J Cell Mol Med. 2020 Jul;24(14):7706-7716. doi: 10.1111/jcmm.15413. Epub 2020 May 26.
The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause of cancer-related death in the United States. The relationship among obesity, T2DM and PC is complex. Due to increase in obesity, diabetes, alcohol consumption and sedentary lifestyle, the mortality due to PC is expected to rise significantly by year 2040. The underlying mechanisms by which diabetes and obesity contribute to pancreatic tumorigenesis are not well understood. Furthermore, metabolism and microenvironment within the pancreas can also modulate pancreatic carcinogenesis. The risk of PC on a population level may be reduced by modifiable lifestyle risk factors. In this review, the interactions of diabetes and obesity to PC development were summarized, and novel strategies for the prevention and treatment of diabetes and PC were discussed.
在最近几十年，西方世界的肥胖症和 2 型糖尿病（T2DM）的发病率急剧上升。根据美国癌症协会的数据，胰腺癌（PC）是美国癌症相关死亡的第四大主要原因。肥胖症、T2DM 和 PC 之间的关系很复杂。由于肥胖症、糖尿病、饮酒和久坐不动的生活方式增加，预计到 2040 年，PC 导致的死亡率将显著上升。糖尿病和肥胖症促进胰腺肿瘤发生的潜在机制尚不清楚。此外，胰腺内的代谢和微环境也可以调节胰腺癌变。通过可改变的生活方式风险因素，可以降低人群中 PC 的风险。在这篇综述中，总结了糖尿病和肥胖症对 PC 发展的相互作用，并讨论了预防和治疗糖尿病和 PC 的新策略。
