Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Suita, Japan.
Eur J Immunol. 2011 Nov;41(11):3097-100. doi: 10.1002/eji.201142115. Epub 2011 Oct 20.
Treg cells are critical for the maintenance of immune homeostasis and suppression of naturally occurring self-reactive T cells; however, in order to induce suppression Treg cells must first be activated via their T-cell receptor by recognition of specific antigen-MHC complexes. In this issue of the European Journal of Immunology, Föhse et al. [Eur. J. Immunol. 2011. 41: 3101-3113.] shed light on the important question of the role of TCR diversity on Treg-cell function by demonstrating that high TCR diversity is crucial for optimal Treg-cell expansion, peripheral reshaping of the Treg-cell TCR repertoire and in vivo suppressive capacity. In this Commentary, we discuss these findings and also propose a simple mathematical model to aid in the understanding of the relationship between Treg-cell TCR diversity and the level of suppression delivered by Treg cells in vivo.
调节性 T 细胞（Treg 细胞）对于维持免疫稳态和抑制天然自身反应性 T 细胞至关重要；然而，为了诱导抑制，Treg 细胞必须首先通过其 T 细胞受体被特定的抗原 MHC 复合物识别而被激活。在本期的《欧洲免疫学杂志》中，Föhse 等人[Eur. J. Immunol. 2011. 41: 3101-3113.]通过证明高 TCR 多样性对于 Treg 细胞的最佳扩增、外周重塑 Treg 细胞 TCR 库以及体内抑制能力至关重要，阐明了 TCR 多样性对 Treg 细胞功能的重要问题。在这篇评论中，我们讨论了这些发现，并提出了一个简单的数学模型，以帮助理解 Treg 细胞 TCR 多样性与 Treg 细胞在体内提供的抑制水平之间的关系。
