手性双功能叔胺硫脲催化的吲哚啉类化合物的不对称羟胺化反应：具有季立体中心的 3-氨基-2-氧吲哚啉的构建。
Asymmetric hydroxyamination of oxindoles catalyzed by chiral bifunctional tertiary amine thiourea: construction of 3-amino-2-oxindoles with quaternary stereocenters.
机构信息
Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
出版信息
Org Biomol Chem. 2012 Jan 14;10(2):236-9. doi: 10.1039/c1ob06413d. Epub 2011 Oct 21.
PMID:22016069
Abstract
Chiral bifunctional tertiary amine thiourea was applied to catalyze the asymmetric hydroxyamination of 3-subsituted oxindoles with nitrosobenzene to construct 3-amino-2-oxindoles with quaternary stereocenters in good yields (up to 91%) and enantioselectivities (up to 90% ee).
摘要
手性双功能叔胺硫脲被应用于催化 3-取代的氧化吲哚与亚硝基苯的不对称羟胺化反应，以高产率（高达 91%）和对映选择性（高达 90%ee）构建具有季立体中心的 3-氨基-2-氧化吲哚。
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