Freeman Hospital, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, UK.
QJM. 2012 Mar;105(3):235-40. doi: 10.1093/qjmed/hcr184. Epub 2011 Oct 20.
Fatigue is a complex, disabling symptom in non-CF bronchiectasis (nCF-Br). Fatigue can be formally measured using the validated fatigue impact scale (FIS). The relationship between fatigue and clinically important factors such as airflow obstruction, breathlessness or Pseudomonas aeruginosa infection in nCF-Br is unclear.
To measure the correlation between FIS scores and markers of disease severity in nCF-Br.
A prospective cohort study.
Patients attending a specialist service were studied. Lung function (FEV(1)% predicted), Medical Research Council dyspnoea score (MRCD), sputum culture results and FIS were recorded. Patients were categorized according to sputum culture into three subgroups: Pseudomonas 'colonization', 'isolation' and neither.
One hundred and seventeen consecutive patients were included. Average FEV(1)% predicted was 64% (SD ±28%). Twelve (10%) patients had Pseudomonas aeruginosa isolation; 47 (40%) patients had P. aeruginosa colonization. Fatigue levels were similar in patients with and without colonization (median 38 versus 32, P = 0.155). Significant fatigue (FIS > 40) was similar in all three Pseudomonas subgroups (P = 0.31, chi-square). Fatigue correlated with MRCD score (r = 0.57, P < 0.001) and FEV(1)% predicted (r = -0.30, P = 0.001). FEV(1)% predicted was lower in patients who had ever isolated or been colonized with P. aeruginosa (P ≤ 0.001).
There are significant correlations between FIS score and MRCD score and FEV(1)% predicted in bronchiectasis. Pseudomonas aeruginosa infection appears to be associated with poorer lung function, and higher MRCD scores, yet there is no significant association between P. aeruginosa status and fatigue.
疲劳是非囊性纤维化支气管扩张症（nCF-Br）患者的一种复杂、致残症状。疲劳可以通过经过验证的疲劳影响量表（FIS）进行正式测量。在 nCF-Br 中，疲劳与气流阻塞、呼吸困难或铜绿假单胞菌感染等临床重要因素之间的关系尚不清楚。
测量 FIS 评分与 nCF-Br 疾病严重程度标志物之间的相关性。
前瞻性队列研究。
研究了就诊于专科服务的患者。记录肺功能（FEV1%预计值）、医学研究委员会呼吸困难评分（MRCD）、痰培养结果和 FIS。根据痰培养结果将患者分为三组：铜绿假单胞菌“定植”、“分离”和“两者均无”。
共纳入 117 例连续患者。平均 FEV1%预计值为 64%（标准差 ±28%）。12 例（10%）患者分离出铜绿假单胞菌；47 例（40%）患者定植铜绿假单胞菌。定植患者的疲劳水平与无定植患者相似（中位数 38 对 32，P=0.155）。三组铜绿假单胞菌患者的显著疲劳（FIS>40）相似（P=0.31，卡方检验）。疲劳与 MRCD 评分呈正相关（r=0.57，P<0.001）和 FEV1%预计值呈负相关（r=-0.30，P=0.001）。与从未分离或定植过铜绿假单胞菌的患者相比，曾分离或定植过铜绿假单胞菌的患者 FEV1%预计值更低（P≤0.001）。
在支气管扩张症患者中，FIS 评分与 MRCD 评分和 FEV1%预计值之间存在显著相关性。铜绿假单胞菌感染似乎与肺功能下降和更高的 MRCD 评分相关，但铜绿假单胞菌状态与疲劳之间无显著相关性。
