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在预先形成的种子细丝存在下的成核聚合。

Nucleated polymerisation in the presence of pre-formed seed filaments.

作者信息

Cohen Samuel I A, Vendruscolo Michele, Dobson Christopher M, Knowles Tuomas P J

机构信息

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

出版信息

Int J Mol Sci. 2011;12(9):5844-52. doi: 10.3390/ijms12095844. Epub 2011 Sep 9.

DOI:10.3390/ijms12095844
PMID:22016630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3189754/
Abstract

We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting cases of a reaction starting from purely soluble material and for a reaction where no new growth nuclei are formed.

摘要

我们重新审视了成核聚合的经典问题，并得出了一系列精确结果，这些结果描述了在介于从纯可溶材料开始反应的著名极限情况和不形成新生长核的反应之间的系统中的聚合过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a01/3189754/e662c0f0fa47/ijms-12-05844f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a01/3189754/e662c0f0fa47/ijms-12-05844f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a01/3189754/e662c0f0fa47/ijms-12-05844f1.jpg

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2
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3
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4
Stochastic master equation for early protein aggregation in the transthyretin amyloid disease.转甲状腺素淀粉样变性病中早期蛋白质聚集的随机主方程。
Sci Rep. 2020 Jul 24;10(1):12437. doi: 10.1038/s41598-020-69319-x.
5
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