Wang Zhiguo, Wang Danqiao, Yu Youhua, Li Yikui, Sui Yu, Cui Haifeng
Experimental Research Center, China Academy of Chinese Medical Scinces, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(14):1842-4.
To establish animal model of histamine-induced anaphylactoid reactions on Beagle dogs through intravenous injection of histamine phosphate injection.
Anaphylactoid reactions was determined according to the changes of praxiology and blood pressure of Beagle dogs after one intravenous injection of histamine phosphate injection.
It showed that typical anaphylactoid reactions be caused by histamine phosphate injection on Beagle dogs, and the response of the high-dose group was more obvious than that of the low-dose group.
Intravenous injection of histamine phosphate injection could simulate Beagle dogs to bring typical clinical anaphylactoid reaction, that could be used as a sensitive animal model to evaluate anaphylactoid reaction of traditional Chinese medicine injections (TCMIs) in the pre-clinical experiments of both TCMIs and their composition.
通过静脉注射磷酸组胺注射液建立比格犬组胺诱导类过敏反应的动物模型。
根据比格犬静脉注射一次磷酸组胺注射液后行为学和血压的变化来判定类过敏反应。
结果表明磷酸组胺注射液可引起比格犬典型的类过敏反应，且高剂量组的反应比低剂量组更明显。
静脉注射磷酸组胺注射液可模拟比格犬产生典型的临床类过敏反应，可作为在中药注射剂及其成分的临床前实验中评估中药注射剂类过敏反应的敏感动物模型。
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