Hu Jiang, Zhang Lanchun, Zhao Qinshi
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
Zhongguo Zhong Yao Za Zhi. 2011 Jul;36(14):1969-74.
To study the chemical constituents of Excoecaria acerifclia.
Column chromatography on Silica gel and Sephadex LH-20 were applied for isolation and purification of the constituents. The structures were elucidated on the basis of spectrascopic analysis, chemical evidences and by comparison with the data reported in the literature.
From the crude EtOAc fraction of Excoecaria acerifclia F. Didr, 14 compounds were isolated and identified as 7,8-trans-4,5,9-trihydroxy-3,3',9'-trimethoxy-7-O-5',8-O-4'-neolignan (1), 7,8-trans 4,5,9,9'-tetrahydroxy-3,3'-dimethoxy-7-O-5',8-O-4'-neolignan (2), malloapelin C (3), sy-ringaresinol (4), 2alpha,3beta,24-trihydroxy-12-ursen-28-oic acid (5), 11-hydroxy-3-oxo-12-ursen-28-oic acid (6), 6-hydroxy-20 (29)-lupen-3-one (7), isolupenyl acetate (8), kaempferol (9), quercetin (10), apigenin (11), catechin (12), kamepferol-3-O-beta-D-galactopyranoside (13), and catechin (6-->8) catechin (14).
Compound 1 was new, the remained compounds were isolated and identified from E. acerifclia for the first time. Among them, compounds 5-8 are triterpenoids, while the other compounds are phenylpropanoids.
研究山漆茎的化学成分。
采用硅胶柱色谱和葡聚糖凝胶LH - 20柱色谱对化合物进行分离纯化。通过光谱分析、化学证据并与文献报道的数据进行比较来阐明化合物的结构。
从山漆茎的乙酸乙酯粗提物中分离鉴定出14个化合物，分别为7,8 - 反式 - 4,5,9 - 三羟基 - 3,3',9'-三甲氧基 - 7 - O - 5',8 - O - 4'-新木脂素（1）、7,8 - 反式 - 4,5,9,9'-四羟基 - 3,3'-二甲氧基 - 7 - O - 5',8 - O - 4'-新木脂素（2）、马勒阿佩林C（3）、丁香树脂醇（4）、2α,3β,24 - 三羟基 - 12 - 乌苏 - 28 - 酸（5）、11 - 羟基 - 3 - 氧代 - 12 - 乌苏 - 28 - 酸（6）、6 - 羟基 - 20（29）- 羽扇豆 - 3 - 酮（7）、异羽扇豆醇乙酸酯（(^{8})）、山柰酚（9）、槲皮素（10）、芹菜素（11）、儿茶素（12）、山柰酚 - 3 - O - β - D - 吡喃半乳糖苷（13）和儿茶素（6→8）儿茶素（14）。
化合物1为新化合物，其余化合物均为首次从山漆茎中分离鉴定得到。其中，化合物5 - 8为三萜类化合物，其他化合物为苯丙素类化合物。
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