[无梗五加果实化学成分的分离与鉴定]
[Isolation and identification of chemical constituents of fruits of Acanthopanax sessiliflorus].
作者信息
Yang Chunjuan, An Qi, Song Yang, Xiong Zhili, Li Famei
机构信息
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2009 Mar;34(6):715-7.
OBJECTIVE
To isolate and elucidate the chemical constituents of the fruits of Acanthopanax sessiliflorus.
METHOD
Isolation and purification were carried out on the column chromatography of silica gel and Sephadex LH-20. Their structures were elucidated on basis of physicochemical properties and spectral data.
RESULT
Nine compounds were isolated and identified as oleanolic acid-3-O-6'-O-methyl-beta-D-glucuronopyranoside (1), 22-alpha-hydroxychiisanogenin (2), oleanolic acid-3-O-beta-D-glucuronopyranoside (3), oleanolic acid-3-O-beta-D-glucopyranoside (4), oleanolic acid (5), chiisanogenin (6), (-)-sesamin (7), daucosterol (8), beta-sitosterol (9).
CONCLUSION
Compound 1 is obtained from the genus Acanthopanax genus for the first time. Compounds 2-5 are isolated from this plant for the first time.
目的
分离并阐明无梗五加果实的化学成分。
方法
通过硅胶柱色谱和葡聚糖凝胶LH - 20进行分离纯化。根据理化性质和光谱数据阐明其结构。
结果
分离并鉴定出9种化合物，分别为齐墩果酸 - 3 - O - 6'- O - 甲基 - β - D - 葡萄糖醛酸吡喃糖苷（1）、22 - α - 羟基齐墩果烷型皂苷元（2）、齐墩果酸 - 3 - O - β - D - 葡萄糖醛酸吡喃糖苷（3）、齐墩果酸 - 3 - O - β - D - 葡萄糖吡喃糖苷（4）、齐墩果酸（5）、齐墩果烷型皂苷元（6）、（ - ） - 芝麻素（7）、胡萝卜苷（8）、β - 谷甾醇（9）。
结论
化合物1首次从五加属植物中获得。化合物2 - 5首次从该植物中分离得到。
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