Exp Dermatol. 2011 Dec;20(12):1022-4. doi: 10.1111/j.1600-0625.2011.01378.x. Epub 2011 Oct 20.
Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigoid (BP). Correlations between these cells and disease severity of BP were also evaluated. Immunohistochemical studies showed that both IL-17+ and Foxp3+ cells were present in higher numbers in BP lesions, compared with control skin. IL-17/CD4 ratio in BP was significantly higher than that in PF. Foxp3/CD4 ratio in BP was significantly less than that in either PV or PF. There were no obvious correlations between these cells and disease severity of BP. This study suggests that, compared with pemphigus, BP shows more Th17 cell-related inflammation and less Treg-related regulation.
Th17 细胞在自身免疫性疾病的发病机制中起着关键作用。我们之前报道过，Th17 细胞被募集到寻常型天疱疮（PV）和落叶型天疱疮（PF）的皮损皮肤中。本研究旨在评估大疱性类天疱疮（BP）皮损中的 Th17 细胞和 Treg 细胞，并评估这些细胞与 BP 严重程度的相关性。免疫组化研究表明，与正常皮肤相比，BP 皮损中 IL-17+和 Foxp3+细胞数量更多。BP 中的 IL-17/CD4 比值明显高于 PF。BP 中的 Foxp3/CD4 比值明显低于 PV 或 PF。这些细胞与 BP 严重程度之间没有明显的相关性。本研究表明，与天疱疮相比，BP 显示出更多的 Th17 细胞相关炎症和更少的 Treg 相关调节。
