Department of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland.
J Sports Sci. 2012;30(1):31-5. doi: 10.1080/02640414.2011.623710. Epub 2011 Oct 24.
The aims of this study were to determine the distribution of the AMPD1 genotype among groups of high-level Polish power-oriented athletes, and to investigate potential associations between genetic polymorphism in exon 2 of the AMPD1 gene and power-oriented athlete status. Altogether, 158 male Polish power-oriented athletes were genotyped by PCR-RFLP. The genetic control group comprised 160 unrelated male volunteers. We observed significant differences in genotype distribution when all 158 athletes (89.25% CC, 10.75% CT, 0.00% TT; P = 0.0025) were compared with controls (75.00% CC, 23.75% CT, 1.25% TT). A significant deficiency of the T allele was noted in all subgroups (short-distance runners: 5.21%, P = 0.032; short-distance swimmers: 5.56%, P = 0.031; weightlifters: 5.36%, P = 0.024) compared with controls (13.13%), while this trend was even stronger when the frequency of the T allele was compared between controls and all 158 athletes (5.38%, P = 0.0007). Our results indicate a lower frequency of the AMPD1 exon 2 T34 allele in elite Polish power-oriented athletes. Our data suggest that the C allele may help athletes to attain elite status in power-oriented sports.
本研究的目的是确定 AMPD1 基因型在波兰高水平力量型运动员群体中的分布，并探讨 AMPD1 基因外显子 2 遗传多态性与力量型运动员身份之间的潜在关联。共对 158 名波兰力量型男性运动员进行了 PCR-RFLP 基因分型。遗传对照组包括 160 名无关的男性志愿者。当将所有 158 名运动员（89.25%CC、10.75%CT、0.00%TT；P=0.0025）与对照组（75.00%CC、23.75%CT、1.25%TT）进行比较时，我们观察到基因型分布存在显著差异。在所有亚组（短跑运动员：5.21%，P=0.032；短距离游泳运动员：5.56%，P=0.031；举重运动员：5.36%，P=0.024）中，T 等位基因的明显缺乏与对照组（13.13%）相比，而当将 T 等位基因的频率与对照组和所有 158 名运动员（5.38%，P=0.0007）进行比较时，这种趋势甚至更强。我们的结果表明，波兰高水平力量型运动员 AMPD1 外显子 2 T34 等位基因的频率较低。我们的数据表明，C 等位基因可能有助于运动员在力量型运动中达到精英水平。
