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AMPD1基因C34T多态性对心血管疾病患者心脏指数、血压及预后的影响：一项荟萃分析

Effects of AMPD1 gene C34T polymorphism on cardiac index, blood pressure and prognosis in patients with cardiovascular diseases: a meta-analysis.

作者信息

Feng Ai-Fang, Liu Zhong-Hui, Zhou Shu-Long, Zhao Shi-Yuan, Zhu Yan-Xin, Wang Huai-Xin

机构信息

Department of Emergency, Weifang Yidu Central Hospital, No. 4138, Linglongshan Southern Road, Weifang, 262500, People's Republic of China.

出版信息

BMC Cardiovasc Disord. 2017 Jul 3;17(1):174. doi: 10.1186/s12872-017-0608-0.

DOI:10.1186/s12872-017-0608-0
PMID:28673246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5496365/
Abstract

BACKGROUND

The meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD).

METHODS

Eligible studies were retrieved through a comprehensive search of electronic databases and manual search. Then the high-quality studies met the rigorous inclusion and exclusion criteria, as well as related to the subject was selected for the study. Comprehensive data analyses were conducted using STATA software 12.0.

RESULTS

The study results revealed that CVD patients with CT + TT genotype of AMPD1 C34T polymorphism presented elevated left ventricular ejection fraction (LVEF) (%) and reduced left ventricular end diastolic dimension (LVEDD) (mm) as compared with CC genotype, moreover, the subgroup analysis found that the LVEF (%) was markedly higher in heart failure (HF) patients carrying CT + TT genotype than CC genotype. Besides, the systolic blood pressure (SBP) (mmHg) in CVD patients with CT + TT genotype was obviously decreased in contrast with the CC genotype. Patients suffered from HF with different genotypes (CT + TT and CC) of AMPD1 C34T polymorphism exhibited no significant differences in total survival rate and cardiac survival rate.

CONCLUSIONS

Our current meta-analysis indicated that the T allele of AMPD1 gene C34T polymorphism may be correlated with LVEF, LVEDD and SBP, which plays a protective role in the cardiac functions and blood pressure in CVD patients, but had no effects on total survival rate and cardiac survival rate for HF.

摘要

背景

本荟萃分析旨在评估AMPD1基因C34T多态性对心血管疾病（CVD）患者心功能指标、血压及预后的影响。

方法

通过全面检索电子数据库及手工检索来获取符合条件的研究。然后选择符合严格纳入和排除标准且与该主题相关的高质量研究进行分析。使用STATA软件12.0进行综合数据分析。

结果

研究结果显示，与CC基因型相比，AMPD1基因C34T多态性为CT + TT基因型的CVD患者左心室射血分数（LVEF）（%）升高，左心室舒张末期内径（LVEDD）（mm）减小。此外，亚组分析发现，携带CT + TT基因型的心力衰竭（HF）患者的LVEF（%）明显高于CC基因型患者。此外，与CC基因型相比，AMPD1基因C34T多态性为CT + TT基因型的CVD患者收缩压（SBP）（mmHg）明显降低。不同基因型（CT + TT和CC）的AMPD1基因C34T多态性HF患者的总生存率和心脏生存率无显著差异。

结论

我们目前的荟萃分析表明，AMPD1基因C34T多态性的T等位基因可能与LVEF、LVEDD和SBP相关，对CVD患者的心脏功能和血压起保护作用，但对HF患者的总生存率和心脏生存率无影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/c90a26089357/12872_2017_608_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/e064e64eb28e/12872_2017_608_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/d3caccf511fa/12872_2017_608_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/41a07996c0ad/12872_2017_608_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/1a185849a59d/12872_2017_608_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/c90a26089357/12872_2017_608_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/e064e64eb28e/12872_2017_608_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/d3caccf511fa/12872_2017_608_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/41a07996c0ad/12872_2017_608_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/1a185849a59d/12872_2017_608_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f19/5496365/c90a26089357/12872_2017_608_Fig5_HTML.jpg

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