Kim S
Laboratory of Oral Physiology, Columbia University, School of Dental and Oral Surgery, New York.
J Endod. 1990 Feb;16(2):48-53. doi: 10.1016/S0099-2399(06)81563-3.
The two key components in pulpal inflammation are microcirculation and sensory nerve activity. With advancement of techniques they can be measured simultaneously in the same tooth. Excitation of A-delta fibers seems to have an insignificant effect on pulpal blood flow (PBF), whereas C fiber activation causes an increase in PBF. This C fiber-induced PBF increase is caused by neurokinins, especially substance P, which is released from the C fiber nerve terminals. Manipulation of PBF has varying effects on sensory nerve activity. An increase in PBF causes excitation of both A-delta and C fibers via an increase in tissue pressure, whereas flow reduction has an inhibitory effect on A-delta fibers, but no discernible effect on C fiber activity. Understanding of this complex neurovascular relationship in the pulp, especially given the fact that the pulp is in a low compliance system, is prerequisite to more comprehensive characterization of pulpal inflammation.
牙髓炎症的两个关键组成部分是微循环和感觉神经活动。随着技术的进步，可以在同一颗牙齿中同时测量它们。A-δ纤维的兴奋似乎对牙髓血流（PBF）影响不大，而C纤维的激活会导致PBF增加。这种由C纤维引起的PBF增加是由神经激肽，尤其是P物质引起的，P物质从C纤维神经末梢释放。PBF的改变对感觉神经活动有不同的影响。PBF增加会通过组织压力的增加导致A-δ纤维和C纤维兴奋，而血流减少对A-δ纤维有抑制作用，但对C纤维活动没有明显影响。了解牙髓中这种复杂的神经血管关系，特别是考虑到牙髓处于低顺应性系统这一事实，是更全面地描述牙髓炎症的先决条件。
